Neprilysin

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'''Neprilysin''' (NEP), also known as '''neutral endopeptidase''', is a Zn-dependent metalloprotease which degrades small secreted peptides like the beta-amyloid peptide, tachykinin, neurotensin and enkephalins.<ref>PMID: 15134871</ref><ref>PMID: 15544569</ref><ref>PMID: 17476590</ref><ref>PMID: 18393807</ref><ref>PMID: 18470479</ref><ref>PMID: 23684647</ref><ref>PMID: 23883611</ref><ref>PMID: 24391587</ref> Its signalling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP turns off peptide signalling events at the cell surface. NEP is found in brain tissue and is an integral membrane protein.
'''Neprilysin''' (NEP), also known as '''neutral endopeptidase''', is a Zn-dependent metalloprotease which degrades small secreted peptides like the beta-amyloid peptide, tachykinin, neurotensin and enkephalins.<ref>PMID: 15134871</ref><ref>PMID: 15544569</ref><ref>PMID: 17476590</ref><ref>PMID: 18393807</ref><ref>PMID: 18470479</ref><ref>PMID: 23684647</ref><ref>PMID: 23883611</ref><ref>PMID: 24391587</ref> Its signalling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP turns off peptide signalling events at the cell surface. NEP is found in brain tissue and is an integral membrane protein.
==3D structures of neprilysin==
==3D structures of neprilysin==
 +
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[1dmt]] – hNEP extracellular domain + phosphoramidon – human<br />
[[1dmt]] – hNEP extracellular domain + phosphoramidon – human<br />
 +
[[4cth]] - hNEP extracellular domain (mutant) + phosphoramidon<br />
[[1r1h]], [[1r1i]], [[1r1j]], [[1y8j]], [[2qpj]], [[2yb9]] - hNEP extracellular domain + inhibitor<br />
[[1r1h]], [[1r1i]], [[1r1j]], [[1y8j]], [[2qpj]], [[2yb9]] - hNEP extracellular domain + inhibitor<br />
[[2yvc]] – NEP cytoplasmic tail + radixin - mouse
[[2yvc]] – NEP cytoplasmic tail + radixin - mouse

Revision as of 09:15, 6 May 2015

Structure of glycosylated human neprilysin extracellular domain complex with phosphoramidon (PDB entry 1dmt)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Brenton Horne

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