4uhy
From Proteopedia
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| - | ''' | + | ==Crystal structure of the human RGMA-BMP2 complex== |
| - | + | <StructureSection load='4uhy' size='340' side='right' caption='[[4uhy]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4uhy]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhz|4uhz]], [[4ui0|4ui0]], [[4ui1|4ui1]], [[4ui2|4ui2]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uhy RCSB], [http://www.ebi.ac.uk/pdbsum/4uhy PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation. [[http://www.uniprot.org/uniprot/RGMA_HUMAN RGMA_HUMAN]] Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.<ref>PMID:19273616</ref> <ref>PMID:19458235</ref> |
| - | [[ | + | == References == |
| - | [[Category: Bell, C | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bell, C H]] | ||
[[Category: Bishop, B]] | [[Category: Bishop, B]] | ||
[[Category: Elegheert, J]] | [[Category: Elegheert, J]] | ||
| + | [[Category: Healey, E G]] | ||
| + | [[Category: Parra, S Padilla-]] | ||
[[Category: Siebold, C]] | [[Category: Siebold, C]] | ||
| + | [[Category: Axon guidance]] | ||
| + | [[Category: Bone morphogenetic protein pathway]] | ||
| + | [[Category: Cell surface receptor signaling]] | ||
| + | [[Category: Hemojuvelin]] | ||
| + | [[Category: Morphogen]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 12:59, 6 May 2015
Crystal structure of the human RGMA-BMP2 complex
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