This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ui1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal structure of the human RGMC-BMP2 complex== |
| - | + | <StructureSection load='4ui1' size='340' side='right' caption='[[4ui1]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4ui1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhy|4uhy]], [[4uhz|4uhz]], [[4ui0|4ui0]], [[4ui2|4ui2]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ui1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui1 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Hemochromatosis type 2. The disease is caused by mutations affecting the gene represented in this entry. |
| - | [[Category: Bell, C | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation. [[http://www.uniprot.org/uniprot/RGMC_HUMAN RGMC_HUMAN]] Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.[UniProtKB:Q7TQ32] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bell, C H]] | ||
[[Category: Bishop, B]] | [[Category: Bishop, B]] | ||
[[Category: Elegheert, J]] | [[Category: Elegheert, J]] | ||
| + | [[Category: Healey, E G]] | ||
| + | [[Category: Padilla-Parra, S]] | ||
[[Category: Siebold, C]] | [[Category: Siebold, C]] | ||
| + | [[Category: Axon guidance]] | ||
| + | [[Category: Bone morphogenetic protein pathway]] | ||
| + | [[Category: Cell surface receptor signaling]] | ||
| + | [[Category: Hemojuvelin]] | ||
| + | [[Category: Morphogen]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 12:59, 6 May 2015
Crystal structure of the human RGMC-BMP2 complex
| |||||||||||
