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4wu7

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'''Unreleased structure'''
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==HLA-A24 in complex with HIV-1 Nef134-8(2F)==
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<StructureSection load='4wu7' size='340' side='right' caption='[[4wu7]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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The entry 4wu7 is ON HOLD until Apr 30 2016
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4wu7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WU7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WU7 FirstGlance]. <br>
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Authors: Shimizu, A., Yamagata, A., Fukai, S., Iwamoto, A.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4wu5|4wu5]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wu7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wu7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wu7 RCSB], [http://www.ebi.ac.uk/pdbsum/4wu7 PDBsum]</span></td></tr>
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Description: HLA-A24 in complex with HIV-1 Nef134-8(2F)
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</table>
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[[Category: Unreleased Structures]]
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== Disease ==
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[[Category: Iwamoto, A]]
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[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/1A24_HUMAN 1A24_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Fukai, S]]
[[Category: Fukai, S]]
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[[Category: Yamagata, A]]
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[[Category: Iwamoto, A]]
[[Category: Shimizu, A]]
[[Category: Shimizu, A]]
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[[Category: Yamagata, A]]
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[[Category: Hiv-1]]
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[[Category: Hla-a24]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Immunogloburin domain]]
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[[Category: Mhc class i]]
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[[Category: Nef]]

Revision as of 13:01, 6 May 2015

HLA-A24 in complex with HIV-1 Nef134-8(2F)

4wu7, resolution 2.30Å

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