2ix7
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2IX7 is a | + | 2IX7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with SO4 and CYS as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IX7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ubl conjugation]] | [[Category: ubl conjugation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:21:28 2007'' |
Revision as of 12:16, 5 November 2007
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STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V
Overview
A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the, first two IQ motifs of the murine myosin V heavy chain reveals an unusual, CaM conformation. The C-terminal lobe of each CaM adopts a semi-open, conformation that grips the first part of the IQ motif (IQxxxR), whereas, the N-terminal lobe adopts a closed conformation that interacts more, weakly with the second part of the motif (GxxxR). Variable residues in the, IQ motif play a critical role in determining the precise structure of the, bound CaM, such that even the consensus residues of different motifs show, unique interactions with CaM. This complex serves as a model for the lever, arm region of many classes of unconventional myosins, as well as other IQ, motif-containing proteins such as neuromodulin and IQGAPs.
About this Structure
2IX7 is a Protein complex structure of sequences from Mus musculus with SO4 and CYS as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features., Houdusse A, Gaucher JF, Krementsova E, Mui S, Trybus KM, Cohen C, Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19326-31. Epub 2006 Dec 6. PMID:17151196
Page seeded by OCA on Mon Nov 5 14:21:28 2007
Categories: Mus musculus | Protein complex | Cohen, C. | Gaucher, J.F. | Houdusse, A. | Krementsova, E. | Mui, S. | Trybus, K.M. | CYS | SO4 | Acetylation | Actin-binding | Atp-binding | Ca2+ regulation | Calcium | Calmodulin | Calmodulin-binding | Coiled coil | Complex | Contractile protein | Iq motif | Metal binding | Methylation | Motor protein | Myosin | Nucleotide-binding | Phosphorylation | Ubl conjugation
