4zeq
From Proteopedia
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| - | + | ==Crystal Structure of human BFL-1 in complex with tBid BH3 peptide, Northeast Structural Genomics Consortium Target HX9247== | |
| - | + | <StructureSection load='4zeq' size='340' side='right' caption='[[4zeq]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zeq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zeq RCSB], [http://www.ebi.ac.uk/pdbsum/4zeq PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). [[http://www.uniprot.org/uniprot/BID_HUMAN BID_HUMAN]] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.<ref>PMID:14583606</ref> |
| - | [[ | + | == References == |
| - | [[ | + | <references/> |
| - | [[ | + | __TOC__ |
| - | [[ | + | </StructureSection> |
[[Category: Guan, R]] | [[Category: Guan, R]] | ||
| + | [[Category: Mao, L]] | ||
| + | [[Category: Montelione, G T]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Xiao, R]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Bcl-2 family]] | ||
| + | [[Category: Bh3 only]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Nesg]] | ||
| + | [[Category: Psi-biology]] | ||
Revision as of 13:05, 6 May 2015
Crystal Structure of human BFL-1 in complex with tBid BH3 peptide, Northeast Structural Genomics Consortium Target HX9247
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Categories: Guan, R | Mao, L | Montelione, G T | Structural genomic | Xiao, R | Apoptosis | Bcl-2 family | Bh3 only | Complex | Nesg | Psi-biology
