Obscurin
From Proteopedia
(Difference between revisions)
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| - | '''Obscurin''' (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. | + | '''Obscurin''' (Obs) or '''KIAA1556''' is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. |
Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]]. | Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]]. | ||
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**[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR /> | **[[2e7b]] - hObs 6th Ig domain residues 8-97 – human - NMR<BR /> | ||
| + | **[[2dm7]] - hObs 14th Ig domain residues 1157-1251 – NMR<br /> | ||
| + | **[[2gqh]] - hObs 15th Ig domain residues 1253-1346 – NMR<br /> | ||
**[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR /> | **[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR /> | ||
**[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR /> | **[[2edf]] - hObs 2nd Ig domain residues 2826-2915 – NMR<BR /> | ||
| + | **[[2dku]] - hObs Ig domain residues 2915-3004 – NMR<br /> | ||
**[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR /> | **[[2cr6]] - hObs Ig domain residues 2998-3100 – NMR<BR /> | ||
**[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br /> | **[[2yz8]] - hObs 32nd Ig domain residues 3184-3273 <br /> | ||
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**[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR /> | **[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR /> | ||
**[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR /> | **[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR /> | ||
| - | **[[3knb]], [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain <br /> | + | **[[3knb]], [[2wp3]], [[2wwm]], [[4c4k]] – hObs N terminal residues 1-105 + titin M10 domain <br /> |
| + | **[[4uow]] - hObs residues 26829-26925+ titin M10 domain<br /> | ||
**[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br /> | **[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:25, 7 May 2015
Obscurin (Obs) or KIAA1556 is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see Group:MUZIC:Obscurin.
3D structures of obscurin
07-May-2015
