User:Wayne Decatur/Gal 4
From Proteopedia
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| - | Gal4p is a transcriptional activator in'''Saccharomyces cerevisiae''' that regulates the expression of genes to coordinate the response to the carbon source galactose. | + | Gal4p is a transcriptional activator in'''Saccharomyces cerevisiae''' that regulates the expression of genes to coordinate the response to the carbon source galactose. Structures |
<Structure load='Insert PDB code or filename here' size='550' frame='true' align='right' caption='The N-terminal amino acids of Gal4p bound to DNA.' scene='70/701975/1d66_firstglance/1' /> | <Structure load='Insert PDB code or filename here' size='550' frame='true' align='right' caption='The N-terminal amino acids of Gal4p bound to DNA.' scene='70/701975/1d66_firstglance/1' /> | ||
| + | ===DNA Recognition by Gal4p=== | ||
Gal4p is a transcriptional activator in'''Saccharomyces cerevisiae''' that regulates genes in response to the carbon source galactose. | Gal4p is a transcriptional activator in'''Saccharomyces cerevisiae''' that regulates genes in response to the carbon source galactose. | ||
| - | The protein binds as a dimer to a symmetrical 17-base-pair sequence | + | The structure of The protein binds as a dimer to a symmetrical 17-base-pair sequence. Specifically, the consensus Gal4-binding site is a 17-mer of sequence 5′-CGG-N11-CCG-3′. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:1557122</ref><references group="xtra"/> | <ref group="xtra">PMID:1557122</ref><references group="xtra"/> | ||
Revision as of 15:33, 12 May 2015
Gal4p is a transcriptional activator inSaccharomyces cerevisiae that regulates the expression of genes to coordinate the response to the carbon source galactose. Structures
|
DNA Recognition by Gal4p
Gal4p is a transcriptional activator inSaccharomyces cerevisiae that regulates genes in response to the carbon source galactose. The structure of The protein binds as a dimer to a symmetrical 17-base-pair sequence. Specifically, the consensus Gal4-binding site is a 17-mer of sequence 5′-CGG-N11-CCG-3′.
Reference
- Marmorstein R, Carey M, Ptashne M, Harrison SC. DNA recognition by GAL4: structure of a protein-DNA complex. Nature. 1992 Apr 2;356(6368):408-14. PMID:1557122 doi:http://dx.doi.org/10.1038/356408a0
