Phosphoribosyltransferase

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Line 32: Line 32:
**[[4fym]] - PfOPRT – ''Plasmodium falciparum''<br />
**[[4fym]] - PfOPRT – ''Plasmodium falciparum''<br />
**[[4ohc]] – OPRT – ''Burkholderia cenocepacia''<br />
**[[4ohc]] – OPRT – ''Burkholderia cenocepacia''<br />
 +
**[[4paw]] – HpOPRT – ''Helicobacter pylori''<br />
*Orotate phosphoribosyltransferase complex
*Orotate phosphoribosyltransferase complex
Line 40: Line 41:
**[[3mi2]] - hOPRT + pyrazofurin monophosphate<br />
**[[3mi2]] - hOPRT + pyrazofurin monophosphate<br />
**[[4hib]], [[4hkp]] - hOPRT + inhibitor<br />
**[[4hib]], [[4hkp]] - hOPRT + inhibitor<br />
-
**[[3osc]] - BaOPRT + PRPP<BR />
+
**[[3osc]], [[4rv4]] - BaOPRT + PRPP<BR />
**[[1opr]], [[1lh0]] - StOPRT + orotate + PRPP<BR />
**[[1opr]], [[1lh0]] - StOPRT + orotate + PRPP<BR />
**[[2ps1]] - yOPRT + orotate + PRPP<BR />
**[[2ps1]] - yOPRT + orotate + PRPP<BR />
Line 53: Line 54:
**[[1vdm]] - PhHGPRT – ''Pyrococcus horikoshii''<br />
**[[1vdm]] - PhHGPRT – ''Pyrococcus horikoshii''<br />
**[[1z7g]] - hHGPRT <br />
**[[1z7g]] - hHGPRT <br />
-
**[[3h83]], [[3hvu]], [[3o7m]] - BaHGPRT<br />
+
**[[3h83]], [[3hvu]], [[3o7m]], [[4qyi]] - BaHGPRT<br />
**[[3acb]] - TtHGPRT – ''Thermus thermophilus''<br />
**[[3acb]] - TtHGPRT – ''Thermus thermophilus''<br />
**[[3ohp]] - VcHGPRT <br />
**[[3ohp]] - VcHGPRT <br />
**[[4lyy]] – HGPRT – ''Shewanella pealeana''<br />
**[[4lyy]] – HGPRT – ''Shewanella pealeana''<br />
 +
**[[4pfq]] – HGPRT – ''Brachybacterium faecium''<br />
 +
**[[4qri]] – HGPRT – ''Leptospira interrogans''<br />
 +
**[[4rqa]], [[4rqb]] – HGPRT – ''Staphylococcus aureus''<br />
*Hypoxanthine-guanine phosphoribosyltransferase binary complex
*Hypoxanthine-guanine phosphoribosyltransferase binary complex
Line 64: Line 68:
**[[1g9t]] - EcHGPRT + GMP<br />
**[[1g9t]] - EcHGPRT + GMP<br />
**[[1hmp]], [[2vfa]] - hHGPRT + GMP<br />
**[[1hmp]], [[2vfa]] - hHGPRT + GMP<br />
-
**[[3gep]], [[3ggj]] - hHGPRT + guanine derivative<br />
+
**[[3gep]], [[3ggj]], [[4jit]], [[4jls]] - hHGPRT + guanine derivative<br />
**[[3ggc]] - hHGPRT + hypoxanthine derivative<br />
**[[3ggc]] - hHGPRT + hypoxanthine derivative<br />
-
**[[4ijq]] - hHGPRT + inhibitor<br />
+
**[[4ijq]], [[4rab]], [[4rac]], [[4rad]], [[4ran]], [[4rao]], [[4raq]] - hHGPRT + inhibitor<br />
**[[4kn6]] - hHGPRT + antiviral agent<br />
**[[4kn6]] - hHGPRT + antiviral agent<br />
**[[1hgx]] - HGPRT + GMP – ''Tritrichomonas foetus''<br />
**[[1hgx]] - HGPRT + GMP – ''Tritrichomonas foetus''<br />
Line 87: Line 91:
**[[1dqn]] - GiHGPRT + transition state analog<br />
**[[1dqn]] - GiHGPRT + transition state analog<br />
**[[1d6n]] - LdAPRT + AMP derivative<br />
**[[1d6n]] - LdAPRT + AMP derivative<br />
 +
**[[4z1o]] - SsHGPRT + PRPP - ''Sulfolobus solfataricus''<br />
 +
**[[4zfn]] - SsHGPRT + GMP<br />
*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
*Hypoxanthine-guanine phosphoribosyltransferase ternary complex
Line 112: Line 118:
**[[1qpn]] – MtQAPRT + nicotinate mononucleotide <br />
**[[1qpn]] – MtQAPRT + nicotinate mononucleotide <br />
**[[1qpq]] - MtQAPRT + quinolinic acid<br />
**[[1qpq]] - MtQAPRT + quinolinic acid<br />
 +
**[[4r3x]] - hQAPRT + quinolinic acid<br />
**[[3c2o]] - yQAPRT + quinolinic acid<br />
**[[3c2o]] - yQAPRT + quinolinic acid<br />
**[[3c2f]] - yQAPRT + PRPP<BR />
**[[3c2f]] - yQAPRT + PRPP<BR />
Line 117: Line 124:
**[[3c2v]] - yQAPRT + inhibitor + PRPP<BR />
**[[3c2v]] - yQAPRT + inhibitor + PRPP<BR />
**[[4i9a]] – QAPRT + nicotinate mononucleotide – pig<br />
**[[4i9a]] – QAPRT + nicotinate mononucleotide – pig<br />
-
**[[2b7n]] – HpQAPRT + quinolinic acid – ''Helicobacter pylori''<br />
+
**[[2b7n]] – HpQAPRT + quinolinic acid <br />
**[[4kww]] – hQAPRT + phthalate <br />
**[[4kww]] – hQAPRT + phthalate <br />
**[[2b7p]] – HpQAPRT + phthalate <br />
**[[2b7p]] – HpQAPRT + phthalate <br />
**[[2b7q]] – HpQAPRT + nicotinate mononucleotide <br />
**[[2b7q]] – HpQAPRT + nicotinate mononucleotide <br />
 +
**[[4r3y]] – hQAPRT + nicotinate mononucleotide <br />
*'''Uracil phosphoribosyltransferase'''
*'''Uracil phosphoribosyltransferase'''
Line 140: Line 148:
**[[1i5e]], [[2igb]] - UPRT + UMP – ''Bacillus caldolyticus''<br />
**[[1i5e]], [[2igb]] - UPRT + UMP – ''Bacillus caldolyticus''<br />
**[[1jls]] - TgUPRT (mutant) + uracil + PRPP<BR />
**[[1jls]] - TgUPRT (mutant) + uracil + PRPP<BR />
-
**[[1vst]], [[3g6w]] - SsUPRT + GTP + PRPP – ''Sulfolobus solfataricus''
+
**[[1vst]], [[3g6w]] - SsUPRT + GTP + PRPP
*'''Adenine phosphoribosyltransferase'''
*'''Adenine phosphoribosyltransferase'''
Line 150: Line 158:
**[[4m0k]] – APRT – ''Rhodothermus marinus''<br />
**[[4m0k]] – APRT – ''Rhodothermus marinus''<br />
**[[4mb6]] – APRT – ''Yersinia pseudotuberculosis''<br />
**[[4mb6]] – APRT – ''Yersinia pseudotuberculosis''<br />
 +
**[[4trb]] – SsAPRT <br />
*Adenine phosphoribosyltransferase complex
*Adenine phosphoribosyltransferase complex
**[[1qb7]] - LdAPRT + adenine<br />
**[[1qb7]] - LdAPRT + adenine<br />
 +
**[[4trc]] - SsAPRT + adenine<br />
 +
**[[4ts5]] - SsAPRT + AMP<br />
**[[1qb8]] - LdAPRT + AMP<br />
**[[1qb8]] - LdAPRT + AMP<br />
**[[1ore]], [[1zn8]], [[1zn9]] - hAPRT + AMP<br />
**[[1ore]], [[1zn8]], [[1zn9]] - hAPRT + AMP<br />
**[[1mzv]] - LtAPRT + AMP<br />
**[[1mzv]] - LtAPRT + AMP<br />
 +
**[[4ts7]] - SsAPRT + ADP<br />
**[[1zn7]] - hHGPRT + adenine + PRPP<BR />
**[[1zn7]] - hHGPRT + adenine + PRPP<BR />
**[[1l1q]] - GiAPRT + adenine derivative<br />
**[[1l1q]] - GiAPRT + adenine derivative<br />
Line 170: Line 182:
*Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
*Nicotinate mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase complex
-
**[[1jh8]], [[4kpf]] – SeNN:DBI PRT + adenine<br />
+
**[[1jh8]], [[4kqf]] – SeNN:DBI PRT + adenine<br />
**[[1l4e]], [[1l4f]], [[1l4g]], [[1l4h]], [[1l4k]], [[1l4l]], [[1l4m]], [[1l4n]], [[1l5f]], [[1l5k]], [[1l5l]], [[1l5m]], [[1l5n]], [[1l5o]] - SeNN:DBI PRT + product-aldimine complex<br />
**[[1l4e]], [[1l4f]], [[1l4g]], [[1l4h]], [[1l4k]], [[1l4l]], [[1l4m]], [[1l4n]], [[1l5f]], [[1l5k]], [[1l5l]], [[1l5m]], [[1l5n]], [[1l5o]] - SeNN:DBI PRT + product-aldimine complex<br />
**[[1jha]] – SeNN:DBI PRT + AMP + nicotinate<br />
**[[1jha]] – SeNN:DBI PRT + AMP + nicotinate<br />
Line 201: Line 213:
**[[1kgz]] - PcANPRT + PRPP<BR />
**[[1kgz]] - PcANPRT + PRPP<BR />
**[[1zvw]] - MtANPRT + PRPP<BR />
**[[1zvw]] - MtANPRT + PRPP<BR />
-
**[[4ij1]] - MtANPRT + anthranilate derivative <br />
+
**[[4n5v]], [[4n93]] - MtANPRT + PRPP + aminofluorobenzoate<BR />
 +
**[[4owm]], [[4own]], [[4owo]], [[4owq]], [[4ows]], [[4owu]] - MtANPRT + PRPP + anthranilate derivative<BR />
 +
**[[4n8q]] - MtANPRT + aminofluorobenzoate<BR />
 +
**[[4owv]] - MtANPRT + aminobenzoate<BR />
 +
**[[4ij1]], [[4m0r]] - MtANPRT + anthranilate derivative <br />
**[[1zxy]] - SsANPRT + PRPP<BR />
**[[1zxy]] - SsANPRT + PRPP<BR />
**[[3gbr]] - SsANPRT (mutant) + PRPP<BR />
**[[3gbr]] - SsANPRT (mutant) + PRPP<BR />
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**[[2e5d]] - hNMPRT + nicotinamide<br />
**[[2e5d]] - hNMPRT + nicotinamide<br />
**[[3dgr]] - hNMPRT + ADP analog<br />
**[[3dgr]] - hNMPRT + ADP analog<br />
-
**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]] - hNMPRT + inhibitor<br />
+
**[[4jnm]], [[4jr5]], [[4kfn]], [[4kfo]], [[4kfp]], [[4lts]], [[4lv9]], [[4lva]], [[4lvb]], [[4lvd]], [[4lvf]], [[4lvg]], [[4lww]], [[4m6p]], [[4m6q]], [[4n9b]], [[4n9c]], [[4n9d]], [[4n9e]], [[4l4l]], [[4l4m]], [[4o0z]], [[4o10]], [[4o12]], [[4o13]], [[4o14]], [[4o15]], [[4o16]], [[4o17]], [[4o18]], [[4o19]], [[4o1a]], [[4o1b]], [[4o1c]], [[4o1d]], [[4wq6]] - hNMPRT + inhibitor<br />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dhd]], [[3dhf]] - hNMPRT + pyrophosphate + NMN<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
**[[3dkj]], [[3dkl]] - hNMPRT + benzamide + PRPP<BR />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:28, 13 May 2015

Template:STRUCTURE 3l0k

Phosphoribosyltransferase (PRT) are transferases which belong to several classes:
1. Hypoxanthine-guanine PRT (HGPRT). HGPRT is part of the purine biosynthesis and catalyzes the formation of GMP from guanine, xanthosine monophosphate from xanthosine and of inosine monophosphate from hypoxanthine.
2. Orotate PRT (OPRT). OPRT is part of the pyrimidine biosynthesis and catalyzes the formation of orotidine 5’-monophosphate (OMP) from orotate and phosphoribosyl pyrophosphate (PRPP).
3. Quinolinic acid PRT (QAPRT ). QAPRT is a degrading enzyme found in the brain.
4. Uracil PRT (UPRT). UPRT catalyzes the formation of UMP from uracil and PRPP. Adenine PRT (APRT). APRT catalyzes the formation of AMP from adenine and PRPP.
5. Nicotinate nucleotide dimethylbenzimidazole PRT (NN:DBI PRT). NN:DBI PRT is part of riboflavin, porphyrin and chlorophyll biosynthesis.
6. Anthranilate PRT (ANPRT). ANPRT participates in phenylalanine, tyrosine and tryptophan biosynthesis and catalyzes the formation of anthraniline from phosphoribosyl anthranilate.
7. ATP PRT participates in histidine biosynthesis and catalyzes the formation of ATP from phosphoribosyl ATP and diphosphate.
8. Nicotinate PRT (NIPRT). NIPRT catalyzes the formation of nicotinate from nicotinate ribonucleotide and diphosphate.
9. Nicotinamide PRT (NMPRT). NMPRT catalyzes the formation of nicotinamide from nicotinamide ribonucleotide (NMN) and diphosphate.

3D structures of phosphoribosyltransferase

Updated on 13-May-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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