Phosphotriesterase
From Proteopedia
(Difference between revisions)
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to a Jmol applet. Check out the other buttons as well! | to a Jmol applet. Check out the other buttons as well! | ||
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| - | '''Phosphotriesterase''' (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol. PTE has no known natural substrate but has potential in detoxification of organophosphates poisons lethal effects. PTE can detoxify the insecticide paraoxon and the chemical warfare agent sarin. | + | '''Phosphotriesterase''' or '''aryldialkylphosphatase''' (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol. PTE has no known natural substrate but has potential in detoxification of organophosphates poisons lethal effects. PTE can detoxify the insecticide paraoxon and the chemical warfare agent sarin. |
==3D structures of phosphotriesterase== | ==3D structures of phosphotriesterase== | ||
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*Phosphotriesterase complex with metal ion | *Phosphotriesterase complex with metal ion | ||
| - | **[[1hzy]] - BdPTE + Zn<br /> | + | **[[1hzy]], [[4pbe]], [[4pbf]], [[4pcn]], [[4pcp]] - BdPTE + Zn<br /> |
**[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br /> | **[[2ob3]], [[2o4m]], [[2o4q]], [[2oql]] - BdPTE (mutant) + Zn<br /> | ||
**[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]] - BdPTE (mutant) + Co<br /> | **[[3cs2]], [[3upm]], [[3ur2]], [[3ur5]], [[3ura]], [[3urb]], [[3urn]] - BdPTE (mutant) + Co<br /> | ||
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**[[1p6b]] - FlPTE (mutant) + Zn – ''Flavobacterium''<br /> | **[[1p6b]] - FlPTE (mutant) + Zn – ''Flavobacterium''<br /> | ||
**[[2d2j]], [[3a3x]], [[3a4j]], [[3oqe]] - AtPTE (mutant) + Co – ''Agrobacterium tumefaciens''<br /> | **[[2d2j]], [[3a3x]], [[3a4j]], [[3oqe]] - AtPTE (mutant) + Co – ''Agrobacterium tumefaciens''<br /> | ||
| + | **[[3wml]] - AtPTE (mutant) + Co + Fe <br /> | ||
**[[2gvu]] - LvPTE (mutant) + Ca – ''Loligo vulgaris''<br /> | **[[2gvu]] - LvPTE (mutant) + Ca – ''Loligo vulgaris''<br /> | ||
**[[2gvw]] - LvPTE + Ca<br /> | **[[2gvw]] - LvPTE + Ca<br /> | ||
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**[[4h9z]] - GkPTE (mutant) + Fe + Mn<br /> | **[[4h9z]] - GkPTE (mutant) + Fe + Mn<br /> | ||
**[[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br /> | **[[4gy0]], [[4gy1]] – PTE arylesterase variant + Zn – synthetic<br /> | ||
| + | **[[2vc5]] - SsPTE + Co + Fe – ''Sulfolobus solfataricus''<br /> | ||
| + | **[[4ker]], [[4kes]], [[4ket]], [[4keu]], [[4kev]], [[4kez]] - SsPTE (mutant) + Co + Fe <br /> | ||
*Phosphotriesterase ternary complex with metal ion | *Phosphotriesterase ternary complex with metal ion | ||
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**[[4h9x]] - GkPTE (mutant) + lactone derivative + Fe + Zn<br /> | **[[4h9x]] - GkPTE (mutant) + lactone derivative + Fe + Zn<br /> | ||
**[[4e3t]] – BdPTE arylesterase variant + transition state analog + Zn <br /> | **[[4e3t]] – BdPTE arylesterase variant + transition state analog + Zn <br /> | ||
| + | **[[3uf9]] - SsPTE + Co + Fe + fensulfothion<br /> | ||
| + | **[[2vc7]] - SsPTE + Co + Fe + thiophenium derivative<br /> | ||
| + | **[[4kf1]] - SsPTE (mutant) + Co + Fe + thiophenium derivative<br /> | ||
| + | **[[4np7]] - AtPTE (mutant) + Co + Fe + thiophosphate<br /> | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:56, 13 May 2015
Phosphotriesterase or aryldialkylphosphatase (PTE) catalyzes the conversion of aryl dialkyl phosphate to dialkyl phosphate and aryl alcohol. PTE has no known natural substrate but has potential in detoxification of organophosphates poisons lethal effects. PTE can detoxify the insecticide paraoxon and the chemical warfare agent sarin.
3D structures of phosphotriesterase
Updated on 13-May-2015
