2z35

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[[Image:2z35.gif|left|200px]]<br /><applet load="2z35" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2z35.gif|left|200px]]
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caption="2z35, resolution 2.2&Aring;" />
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'''Crystal structure of immune receptor'''<br />
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{{Structure
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|PDB= 2z35 |SIZE=350|CAPTION= <scene name='initialview01'>2z35</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of immune receptor'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2Z35 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z35 OCA].
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2Z35 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z35 OCA].
==Reference==
==Reference==
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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'., Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC, Nat Immunol. 2007 Sep;8(9):975-83. Epub 2007 Aug 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17694060 17694060]
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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'., Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC, Nat Immunol. 2007 Sep;8(9):975-83. Epub 2007 Aug 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17694060 17694060]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: immune system]]
[[Category: immune system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:59:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:51:37 2008''

Revision as of 16:51, 20 March 2008

Image:2z35.gif


PDB ID 2z35

Drag the structure with the mouse to rotate
, resolution 2.2Å
Coordinates: save as pdb, mmCIF, xml



Crystal structure of immune receptor


Overview

All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here we determined the crystal structures of two TCRs encoded by the variable beta-chain 8.2 (V(beta)8.2), each bound to the MHC class II molecule I-A(u), and did energetic mapping of V(alpha) and V(beta) contacts with I-A(u). Together with two previously solved structures of V(beta)8.2-containing TCR-MHC complexes, we found four TCR-I-A complexes with structurally superimposable interactions between the V(beta) loops and the I-A alpha-helix. This examination of a narrow 'slice' of the TCR-MHC repertoire demonstrates what is probably one of many germline-derived TCR-MHC interaction 'codons'.

About this Structure

2Z35 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'., Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC, Nat Immunol. 2007 Sep;8(9):975-83. Epub 2007 Aug 12. PMID:17694060

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