4uzb
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)== |
| + | <StructureSection load='4uzb' size='340' side='right' caption='[[4uzb]], [[Resolution|resolution]] 2.87Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4uzb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UZB FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uzc|4uzc]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uzb RCSB], [http://www.ebi.ac.uk/pdbsum/4uzb PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The latency-associated nuclear antigen (LANA) is the latent origin-binding protein and chromatin anchor of the Kaposi's sarcoma herpesvirus (KSHV/HHV-8) genome. Its C-terminal domain (CTD) binds sequence-specifically to the viral origin of replication, whereas the N-terminal domain links it to nucleosomes of cellular chromatin for long-term persistence in dividing host cells. Here, the crystallization and X-ray data acquisition of a mutant LANA CTD in complex with its wild-type target DNA LBS1 is described. This report describes the rational protein engineering for successful co-crystallization with DNA and X-ray diffraction data collection at room temperature on the high-brilliance third-generation synchrotron PETRA III at DESY, Germany. | ||
| - | + | Crystallization, room-temperature X-ray diffraction and preliminary analysis of Kaposi's sarcoma herpesvirus LANA bound to DNA.,Hellert J, Krausze J, Schulz TF, Luhrs T Acta Crystallogr F Struct Biol Commun. 2014 Nov;70(Pt 11):1570-4. doi:, 10.1107/S2053230X14019906. Epub 2014 Oct 25. PMID:25372834<ref>PMID:25372834</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hellert, J]] | [[Category: Hellert, J]] | ||
| + | [[Category: Krausze, J]] | ||
[[Category: Luhrs, T]] | [[Category: Luhrs, T]] | ||
| - | [[Category: | + | [[Category: Cancer]] |
| + | [[Category: Dna-binding domain]] | ||
| + | [[Category: Gammaherpesvirus]] | ||
| + | [[Category: Hhv-8]] | ||
| + | [[Category: Multicentric castleman's disease]] | ||
| + | [[Category: Oligomerization domain]] | ||
| + | [[Category: Origin-binding domain]] | ||
| + | [[Category: Primary effusion lymphoma]] | ||
| + | [[Category: Rhadinovirus]] | ||
| + | [[Category: Tumor virus]] | ||
| + | [[Category: Viral protein-dna complex]] | ||
Revision as of 12:16, 13 May 2015
KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)
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