4nxr
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide== |
| - | + | <StructureSection load='4nxr' size='340' side='right' caption='[[4nxr]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4nxr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NXR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANS:5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC+ACID(DANSYL+ACID)'>ANS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kzd|3kzd]], [[3kze|3kze]], [[4gvd|4gvd]], [[4gvc|4gvc]], [[4nxq|4nxq]], [[4nxp|4nxp]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nxr RCSB], [http://www.ebi.ac.uk/pdbsum/4nxr PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. [[http://www.uniprot.org/uniprot/NRX2B_HUMAN NRX2B_HUMAN]] Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fuentes, E J]] | ||
| + | [[Category: Hengel, S R]] | ||
[[Category: Liu, X]] | [[Category: Liu, X]] | ||
| - | [[Category: | + | [[Category: Shepherd, T R]] |
| - | [[Category: | + | [[Category: Speckhard, D C]] |
| - | [[Category: | + | [[Category: Beta barrel fold protein]] |
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Peptide binding]] | ||
| + | [[Category: Scaffold signaling protein for cell adhesion and cell junction]] | ||
| + | [[Category: Signaling domain]] | ||
| + | [[Category: Signaling protein-peptide complex]] | ||
| + | [[Category: Specificity mutant]] | ||
Revision as of 12:21, 13 May 2015
Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide
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