This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4nxr
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide== |
| - | + | <StructureSection load='4nxr' size='340' side='right' caption='[[4nxr]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4nxr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NXR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANS:5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC+ACID(DANSYL+ACID)'>ANS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kzd|3kzd]], [[3kze|3kze]], [[4gvd|4gvd]], [[4gvc|4gvc]], [[4nxq|4nxq]], [[4nxp|4nxp]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nxr RCSB], [http://www.ebi.ac.uk/pdbsum/4nxr PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. [[http://www.uniprot.org/uniprot/NRX2B_HUMAN NRX2B_HUMAN]] Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fuentes, E J]] | ||
| + | [[Category: Hengel, S R]] | ||
[[Category: Liu, X]] | [[Category: Liu, X]] | ||
| - | [[Category: | + | [[Category: Shepherd, T R]] |
| - | [[Category: | + | [[Category: Speckhard, D C]] |
| - | [[Category: | + | [[Category: Beta barrel fold protein]] |
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Peptide binding]] | ||
| + | [[Category: Scaffold signaling protein for cell adhesion and cell junction]] | ||
| + | [[Category: Signaling domain]] | ||
| + | [[Category: Signaling protein-peptide complex]] | ||
| + | [[Category: Specificity mutant]] | ||
Revision as of 12:21, 13 May 2015
Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide
| |||||||||||
