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4yc7
From Proteopedia
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| - | ''' | + | ==Crystal structure of human FMNL2 GBD-FH3 Domains bound to Cdc42-GppNHp== |
| - | + | <StructureSection load='4yc7' size='340' side='right' caption='[[4yc7]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yc7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YC7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YC7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yc7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yc7 RCSB], [http://www.ebi.ac.uk/pdbsum/4yc7 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/FMNL2_HUMAN FMNL2_HUMAN]] Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics.<ref>PMID:21834987</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Geyer, M]] | [[Category: Geyer, M]] | ||
| + | [[Category: Kuhn, S]] | ||
| + | [[Category: Armadillo repeat]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Rho gtpase]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 12:25, 13 May 2015
Crystal structure of human FMNL2 GBD-FH3 Domains bound to Cdc42-GppNHp
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