2z66
From Proteopedia
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| - | [[Image:2z66.jpg|left|200px]] | + | [[Image:2z66.jpg|left|200px]] |
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| - | '''Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61''' | + | {{Structure |
| + | |PDB= 2z66 |SIZE=350|CAPTION= <scene name='initialview01'>2z66</scene>, resolution 1.90Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= VLRB.61, TLR4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Eptatretus burgeri, Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2Z66 is a [ | + | 2Z66 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Eptatretus_burgeri,_homo_sapiens Eptatretus burgeri, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z66 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran., Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO, Cell. 2007 Sep 7;130(5):906-17. PMID:[http:// | + | Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran., Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO, Cell. 2007 Sep 7;130(5):906-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17803912 17803912] |
[[Category: Eptatretus burgeri, homo sapiens]] | [[Category: Eptatretus burgeri, homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: innate immunity]] | [[Category: innate immunity]] | ||
[[Category: leucine-rich repeat]] | [[Category: leucine-rich repeat]] | ||
| - | [[Category: | + | [[Category: lp]] |
[[Category: md-2]] | [[Category: md-2]] | ||
[[Category: membrane]] | [[Category: membrane]] | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:52:26 2008'' |
Revision as of 16:52, 20 March 2008
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| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | VLRB.61, TLR4 (Eptatretus burgeri, Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61
Contents |
Overview
TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its activity by binding to the TLR4-MD-2 complex. We determined the structure of the full-length ectodomain of the mouse TLR4 and MD-2 complex. We also produced a series of hybrids of human TLR4 and hagfish VLR and determined their structures with and without bound MD-2 and Eritoran. TLR4 is an atypical member of the LRR family and is composed of N-terminal, central, and C-terminal domains. The beta sheet of the central domain shows unusually small radii and large twist angles. MD-2 binds to the concave surface of the N-terminal and central domains. The interaction with Eritoran is mediated by a hydrophobic internal pocket in MD-2. Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS.
Disease
Known diseases associated with this structure: Colorectal cancer, susceptibility to OMIM:[603030], Endotoxin hyporesponsiveness OMIM:[603030], Longevity, susceptibility to OMIM:[603030], Macular degeneration, age-related, 10 OMIM:[603030]
About this Structure
2Z66 is a Single protein structure of sequence from Eptatretus burgeri, homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran., Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO, Cell. 2007 Sep 7;130(5):906-17. PMID:17803912
Page seeded by OCA on Thu Mar 20 18:52:26 2008
