2z63
From Proteopedia
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| - | [[Image:2z63.jpg|left|200px]] | + | [[Image:2z63.jpg|left|200px]] |
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| - | '''Crystal structure of the TV8 hybrid of human TLR4 and hagfish VLRB.61''' | + | {{Structure |
| + | |PDB= 2z63 |SIZE=350|CAPTION= <scene name='initialview01'>2z63</scene>, resolution 2.00Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= TLR4, VLRB.61 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Homo sapiens, Eptatretus burgeri]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the TV8 hybrid of human TLR4 and hagfish VLRB.61''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2Z63 is a [ | + | 2Z63 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens,_eptatretus_burgeri Homo sapiens, eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z63 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran., Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO, Cell. 2007 Sep 7;130(5):906-17. PMID:[http:// | + | Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran., Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO, Cell. 2007 Sep 7;130(5):906-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17803912 17803912] |
[[Category: Homo sapiens, eptatretus burgeri]] | [[Category: Homo sapiens, eptatretus burgeri]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Park, B S.]] | [[Category: Park, B S.]] | ||
[[Category: immune system]] | [[Category: immune system]] | ||
| - | [[Category: | + | [[Category: lp]] |
[[Category: md-2]] | [[Category: md-2]] | ||
[[Category: tlr4]] | [[Category: tlr4]] | ||
[[Category: toll-like receptor]] | [[Category: toll-like receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:52:28 2008'' |
Revision as of 16:52, 20 March 2008
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| , resolution 2.00Å | |||||||
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| Gene: | TLR4, VLRB.61 (Homo sapiens, Eptatretus burgeri) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the TV8 hybrid of human TLR4 and hagfish VLRB.61
Overview
TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its activity by binding to the TLR4-MD-2 complex. We determined the structure of the full-length ectodomain of the mouse TLR4 and MD-2 complex. We also produced a series of hybrids of human TLR4 and hagfish VLR and determined their structures with and without bound MD-2 and Eritoran. TLR4 is an atypical member of the LRR family and is composed of N-terminal, central, and C-terminal domains. The beta sheet of the central domain shows unusually small radii and large twist angles. MD-2 binds to the concave surface of the N-terminal and central domains. The interaction with Eritoran is mediated by a hydrophobic internal pocket in MD-2. Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS.
About this Structure
2Z63 is a Single protein structure of sequence from Homo sapiens, eptatretus burgeri. Full crystallographic information is available from OCA.
Reference
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran., Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO, Cell. 2007 Sep 7;130(5):906-17. PMID:17803912
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