2z82

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[[Image:2z82.gif|left|200px]]<br /><applet load="2z82" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2z82.gif|left|200px]]
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caption="2z82, resolution 2.6&Aring;" />
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'''Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide'''<br />
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{{Structure
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|PDB= 2z82 |SIZE=350|CAPTION= <scene name='initialview01'>2z82</scene>, resolution 2.6&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> and <scene name='pdbligand=PDJ:(2R)-3-{[(2R)-2-AMINO-3-HYDROXYPROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE'>PDJ</scene>
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|ACTIVITY=
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|GENE= Tlr2, VLRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Mus musculus, Eptatretus burgeri])
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}}
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'''Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2Z82 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_eptatretus_burgeri Mus musculus, eptatretus burgeri] with <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=PDJ:'>PDJ</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z82 OCA].
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2Z82 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus,_eptatretus_burgeri Mus musculus, eptatretus burgeri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z82 OCA].
==Reference==
==Reference==
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Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide., Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO, Cell. 2007 Sep 21;130(6):1071-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17889651 17889651]
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Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide., Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO, Cell. 2007 Sep 21;130(6):1071-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17889651 17889651]
[[Category: Mus musculus, eptatretus burgeri]]
[[Category: Mus musculus, eptatretus burgeri]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: transmembrane]]
[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:00:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:52:44 2008''

Revision as of 16:52, 20 March 2008

Image:2z82.gif


PDB ID 2z82

Drag the structure with the mouse to rotate
, resolution 2.6Å
Ligands: and
Gene: Tlr2, VLRB (Mus musculus, Eptatretus burgeri)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide


Overview

TLR2 in association with TLR1 or TLR6 plays an important role in the innate immune response by recognizing microbial lipoproteins and lipopeptides. Here we present the crystal structures of the human TLR1-TLR2-lipopeptide complex and of the mouse TLR2-lipopeptide complex. Binding of the tri-acylated lipopeptide, Pam(3)CSK(4), induced the formation of an "m" shaped heterodimer of the TLR1 and TLR2 ectodomains whereas binding of the di-acylated lipopeptide, Pam(2)CSK(4), did not. The three lipid chains of Pam(3)CSK(4) mediate the heterodimerization of the receptor; the two ester-bound lipid chains are inserted into a pocket in TLR2, while the amide-bound lipid chain is inserted into a hydrophobic channel in TLR1. An extensive hydrogen-bonding network, as well as hydrophobic interactions, between TLR1 and TLR2 further stabilize the heterodimer. We propose that formation of the TLR1-TLR2 heterodimer brings the intracellular TIR domains close to each other to promote dimerization and initiate signaling.

About this Structure

2Z82 is a Single protein structure of sequence from Mus musculus, eptatretus burgeri. Full crystallographic information is available from OCA.

Reference

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide., Jin MS, Kim SE, Heo JY, Lee ME, Kim HM, Paik SG, Lee H, Lee JO, Cell. 2007 Sep 21;130(6):1071-82. PMID:17889651

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