2mp6
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure and function of the JAK interaction region in the intrinsically disordered N-terminus of SOCS5== |
| - | + | <StructureSection load='2mp6' size='340' side='right' caption='[[2mp6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mp6]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MP6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mp6 RCSB], [http://www.ebi.ac.uk/pdbsum/2mp6 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/SOCS5_MOUSE SOCS5_MOUSE]] SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.<ref>PMID:12242343</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Dagley, L | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Babon, J J]] | ||
| + | [[Category: Chandrashekaran, I R]] | ||
| + | [[Category: Dagley, L F]] | ||
| + | [[Category: Linossi, E M]] | ||
[[Category: Mohanty, B]] | [[Category: Mohanty, B]] | ||
| - | [[Category: | + | [[Category: Murphy, J M]] |
| - | [[Category: Nicholson, S | + | [[Category: Nicholson, S E]] |
| - | [[Category: | + | [[Category: Norton, R S]] |
| - | [[Category: | + | [[Category: Cytokine signalling suppressor]] |
| + | [[Category: Intrinsically unstructured protein]] | ||
| + | [[Category: Jak interaction region]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 12:13, 20 May 2015
Structure and function of the JAK interaction region in the intrinsically disordered N-terminus of SOCS5
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