3wv6
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal Structure of a protease-resistant mutant form of human galectin-9== |
| - | + | <StructureSection load='3wv6' size='340' side='right' caption='[[3wv6]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3wv6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WV6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wv6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wv6 RCSB], [http://www.ebi.ac.uk/pdbsum/3wv6 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/LEG9_HUMAN LEG9_HUMAN]] Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.<ref>PMID:16286920</ref> <ref>PMID:18005988</ref> <ref>PMID:18977853</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Kamitori, S]] | [[Category: Kamitori, S]] | ||
| + | [[Category: Yoshida, H]] | ||
| + | [[Category: Beta sandwich]] | ||
| + | [[Category: Carbohydrate-binding]] | ||
| + | [[Category: Oligosaccharide]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 12:14, 20 May 2015
Crystal Structure of a protease-resistant mutant form of human galectin-9
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