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Proteasome
From Proteopedia
(Difference between revisions)
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**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br /> | **[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br /> | ||
**[[3gpt]], [[3gpw]], [[1g0u]] – y20S core - yeast<br /> | **[[3gpt]], [[3gpw]], [[1g0u]] – y20S core - yeast<br /> | ||
| - | **[[1ryp]] - y20S core (mutant)<br /> | + | **[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]] - y20S core (mutant)<br /> |
| - | **[[ | + | **[[4r3o]] – h20S – human<br /> |
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | **[[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | ||
| - | **[[3c91]], [[3c92]], [[1pma]] – Ta20S core - ''Themoplasma acidophilum''<br /> | + | **[[3c91]], [[3c92]], [[1pma]], [[3j9i]] – Ta20S core - ''Themoplasma acidophilum''<br /> |
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br /> | **[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br /> | ||
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br /> | **[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br /> | ||
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*Proteasome 20S+inhibitor | *Proteasome 20S+inhibitor | ||
| - | **[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]] – y20S core+inhibitor<br /> | + | **[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]] – y20S core+inhibitor<br /> |
| + | **[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]] – y20S (mutant) + inhibitor<br /> | ||
**[[3tdd]], [[4j70]] - y20S core + belactosin<br /> | **[[3tdd]], [[4j70]] - y20S core + belactosin<br /> | ||
| - | **[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]] - y20S core + | + | **[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br /> |
| - | **[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]] - y20S core+ peptide inhibitor<br /> | + | **[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br /> |
**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]] – Mt20S core+inhibitor<br /> | **[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]] – Mt20S core+inhibitor<br /> | ||
**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br /> | **[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br /> | ||
| + | **[[2zcy]] – y20S+syringolin<br /> | ||
| + | **[[4qvl]], [[4qw4]] – y20S + lymphoma drug<br /> | ||
| + | **[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]] – y20S (mutant) + lymphoma drug<br /> | ||
| + | **[[4r67]] – h20S + cancer drug<br /> | ||
**[[3unb]], [[3unf]] – m20S + inhibitor | **[[3unb]], [[3unf]] – m20S + inhibitor | ||
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*Proteasome partial 26S particle | *Proteasome partial 26S particle | ||
| - | **[[1p9c]] – hPRTS subunit 4 C-terminal | + | **[[1p9c]] – hPRTS subunit 4 C-terminal<br /> |
**[[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br /> | **[[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br /> | ||
**[[1uel]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR<br /> | **[[1uel]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR<br /> | ||
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**[[1qym]], [[1uoh]] - hPRTS subunit 10<br /> | **[[1qym]], [[1uoh]] - hPRTS subunit 10<br /> | ||
**[[1tr4]] - hPRTS subunit 10 – NMR<br /> | **[[1tr4]] - hPRTS subunit 10 – NMR<br /> | ||
| + | **[[4nik]] - hPRTS subunit 10 + single-chain Fv<br /> | ||
**[[3t5x]] - hPRTS subunit Dss1 + PCI domain-containing protein 2<br /> | **[[3t5x]] - hPRTS subunit Dss1 + PCI domain-containing protein 2<br /> | ||
**[[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br /> | **[[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br /> | ||
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**[[4ady]] - yPRTS subunit RPN2<br /> | **[[4ady]] - yPRTS subunit RPN2<br /> | ||
**[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br /> | **[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br /> | ||
| + | **[[2mr3]] - yPRTS subunit RPN9 – NMR<br /> | ||
| + | **[[2mqw]] - yPRTS subunit RPN9 N terminal – NMR<br /> | ||
| + | **[[2mri]] - yPRTS subunit RPN9 C terminal – NMR<br /> | ||
**[[4b0z]] - yPRTS subunit RPN12<br /> | **[[4b0z]] - yPRTS subunit RPN12<br /> | ||
**[[2z4d]] - yPRTS subunit RPN13<br /> | **[[2z4d]] - yPRTS subunit RPN13<br /> | ||
Revision as of 06:53, 21 May 2015
Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 α subunits which form the PRTS gate. The two inner rings contain 6 β subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, i.e. the crystal structure of yeast Proteasome (3gpt).
3D Structures of Proteasome
Updated on 21-May-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
