VEGF IN COMPLEX WITH A NEUTRALIZING ANTIBODY

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<scene name='70/701451/Antibodies_fragment_chains/3'>VEGF antibodies chains</scene>
<scene name='70/701451/Antibodies_fragment_chains/3'>VEGF antibodies chains</scene>
<ref>PMID 9753694</ref>
<ref>PMID 9753694</ref>
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This is a default text for your page '''VEGF IN COMPLEX WITH A NEUTRALIZING ANTIBODY'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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'''VEGF IN COMPLEX WITH A NEUTRALIZING ANTIBODY'''
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref name='maor vegf'>PMID:21638687</ref> to the rescue.
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== Backround ==
== Backround ==
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VEGF and anti-VEGF Fab Complex is a 6 chain, 1050 amino acid structure with a sequence taken from Homo sapiens and Mus musculus.
VEGF and anti-VEGF Fab Complex is a 6 chain, 1050 amino acid structure with a sequence taken from Homo sapiens and Mus musculus.
For a guided tour on the structure components use[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ1 FirstGlance]
For a guided tour on the structure components use[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BJ1 FirstGlance]
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VEGF is a <scene name='70/701451/Homodimeric_vegf/1'>homodimeric</scene> protein who belongs to the family of cystine knot growth factors.
VEGF is a <scene name='70/701451/Homodimeric_vegf/1'>homodimeric</scene> protein who belongs to the family of cystine knot growth factors.
while the 4 other chains belongs to the <scene name='70/701451/1bj1_fab_fragment_emphesys/1'>FAB fragment</scene>.
while the 4 other chains belongs to the <scene name='70/701451/1bj1_fab_fragment_emphesys/1'>FAB fragment</scene>.
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VEGF and anti-VEGF Fab Complex
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The structure of the <scene name='70/701451/Receptor_binding_domain/1'>receptor-binding domain</scene> (residues 8–109) of VEGF consists of a central four- stranded β sheet that displays the characteristic cystine knot at one end and possesses a small hydrophobic core at the other end.
The structure of the <scene name='70/701451/Receptor_binding_domain/1'>receptor-binding domain</scene> (residues 8–109) of VEGF consists of a central four- stranded β sheet that displays the characteristic cystine knot at one end and possesses a small hydrophobic core at the other end.
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== Overall Structure ==
 

Revision as of 17:31, 24 May 2015

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Muller YA, Chen Y, Christinger HW, Li B, Cunningham BC, Lowman HB, de Vos AM. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure. 1998 Sep 15;6(9):1153-67. PMID:9753694

Proteopedia Page Contributors and Editors (what is this?)

Maor Hatoel, Michal Harel

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