1a9l
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1A9L is a | + | 1A9L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Structure known Active Site: NUL. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A9L OCA]. |
==Reference== | ==Reference== | ||
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[[Category: rna structure]] | [[Category: rna structure]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:22:54 2007'' |
Revision as of 12:17, 5 November 2007
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SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES
Overview
The structure of the bulge-helix-bulge motif that constitutes the, intron/exon splice site in H. volcanii pre-tRNATrp has been determined by, NMR spectroscopy. The conformations of the two 3 nt bulges, where the, pre-tRNA is cleaved, are stabilized by stacking interactions between bulge, nucleotides and bases in the adjacent Watson-Crick helices and by a, network of backbone hydrogen bonds. Both bulges are presented on the same, minor groove face of the central 4 bp helix, and the overall structure has, approximate two-fold symmetry, which makes it well-suited for attack by, archaeal splicing endonucleases, which are symmetric dimers.
About this Structure
1A9L is a Protein complex structure of sequences from [1]. Structure known Active Site: NUL. Full crystallographic information is available from OCA.
Reference
Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:9660971
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