328d
From Proteopedia
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| - | [[Image:328d.jpg|left|200px]] | + | [[Image:328d.jpg|left|200px]] |
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| - | '''STRUCTURE OF A D(CGCGAATTCGCG)2-SN7167 COMPLEX''' | + | {{Structure |
| + | |PDB= 328d |SIZE=350|CAPTION= <scene name='initialview01'>328d</scene>, resolution 2.600Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SN7:4-[4-[2-AMINO-4-[4,6-(N-METHYLQUINOLINIUM)AMINO]BENZAMIDO]ANILINO]-N-METHYLPYRIDINIUM MESYLATE'>SN7</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''STRUCTURE OF A D(CGCGAATTCGCG)2-SN7167 COMPLEX''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 328D is a [ | + | 328D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=328D OCA]. |
==Reference== | ==Reference== | ||
| - | Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2., Squire CJ, Clark GR, Denny WA, Nucleic Acids Res. 1997 Oct 15;25(20):4072-8. PMID:[http:// | + | Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2., Squire CJ, Clark GR, Denny WA, Nucleic Acids Res. 1997 Oct 15;25(20):4072-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9321660 9321660] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Clark, G R.]] | [[Category: Clark, G R.]] | ||
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[[Category: complexed with drug]] | [[Category: complexed with drug]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:54:39 2008'' |
Revision as of 16:54, 20 March 2008
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| , resolution 2.600Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF A D(CGCGAATTCGCG)2-SN7167 COMPLEX
Overview
The X-ray crystal structure of the complex between the synthetic antitumour and antiviral DNA binding ligand SN 7167 and the DNA oligonucleotide d(CGCGAATTCGCG)2 has been determined to an R factor of 18.3% at 2.6 A resolution. The ligand is located within the minor groove and covers almost 6 bp with the 1-methylpyridinium ring extending as far as the C9-G16 base pair and the 1-methylquinolinium ring lying between the G4-C21 and A5-T20 base pairs. The ligand interacts only weakly with the DNA, as evidenced by long range contacts and shallow penetration into the groove. This structure is compared with that of the complex between the parent compound SN 6999 and the alkylated DNA sequence d(CGC[e6G]AATTCGCG)2. There are significant differences between the two structures in the extent of DNA bending, ligand conformation and groove binding.
About this Structure
328D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2., Squire CJ, Clark GR, Denny WA, Nucleic Acids Res. 1997 Oct 15;25(20):4072-8. PMID:9321660
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