3lru
From Proteopedia
(Difference between revisions)
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<StructureSection load='3lru' size='340' side='right' caption='[[3lru]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='3lru' size='340' side='right' caption='[[3lru]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3lru]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3lru]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LRU FirstGlance]. <br> |
- | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRP8, PRPC8, PRPF8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRP8, PRPC8, PRPF8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lru RCSB], [http://www.ebi.ac.uk/pdbsum/3lru PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lru RCSB], [http://www.ebi.ac.uk/pdbsum/3lru PDBsum]</span></td></tr> | ||
</table> | </table> | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Protein folding involves the formation of secondary structural elements from the primary sequence and their association with tertiary assemblies. The relation of this primary sequence to a specific folded protein structure remains a central question in structural biology. An increasing body of evidence suggests that variations in homologous sequence ranging from point mutations to substantial insertions or deletions can yield stable proteins with markedly different folds. Here we report the structural characterization of domain IV (D4) and DeltaD4 (polypeptides with 222 and 160 amino acids, respectively) that differ by virtue of an N-terminal deletion of 62 amino acids (28% of the overall D4 sequence). The high-resolution crystal structures of the monomeric D4 and the dimeric DeltaD4 reveal substantially different folds despite an overall conservation of secondary structure. These structures show that the formation of tertiary structures, even in extended polypeptide sequences, can be highly context dependent, and they serve as a model for structural plasticity in protein isoforms. | ||
+ | |||
+ | Context-dependent remodeling of structure in two large protein fragments.,Schellenberg MJ, Ritchie DB, Wu T, Markin CJ, Spyracopoulos L, MacMillan AM J Mol Biol. 2010 Oct 1;402(4):720-30. Epub 2010 Aug 14. PMID:20713060<ref>PMID:20713060</ref> | ||
+ | |||
+ | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
+ | </div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Human]] |
[[Category: MacMillan, A M]] | [[Category: MacMillan, A M]] | ||
[[Category: Ritchie, D B]] | [[Category: Ritchie, D B]] |
Revision as of 10:02, 27 May 2015
hPRP8 Non-Native Subdomain
|
Categories: Human | MacMillan, A M | Ritchie, D B | Schellenberg, M J | Alternate folding of protein | Disease mutation | Mrna processing | Mrna splicing | Nucleus | Phosphoprotein | Retinitis pigmentosa | Ribonucleoprotein | Rna binding protein | Rna-binding | Sensory transduction | Spliceosome | Vision