399d

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[[Image:399d.gif|left|200px]]<br /><applet load="399d" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:399d.gif|left|200px]]
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caption="399d, resolution 1.9&Aring;" />
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'''STRUCTURE OF D(CGCCCGCGGGCG)'''<br />
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{{Structure
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|PDB= 399d |SIZE=350|CAPTION= <scene name='initialview01'>399d</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF D(CGCCCGCGGGCG)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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399D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA].
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399D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=399D OCA].
==Reference==
==Reference==
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Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9917405 9917405]
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Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9917405 9917405]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Fernandez, L G.]]
[[Category: Fernandez, L G.]]
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[[Category: double helix]]
[[Category: double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:55:21 2008''

Revision as of 16:55, 20 March 2008

Image:399d.gif


PDB ID 399d

Drag the structure with the mouse to rotate
, resolution 1.9Å
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF D(CGCCCGCGGGCG)


Overview

We have determined the structure of the dodecamer duplex d(CGCCCGCGGGCG)2. A careful use of the molecular replacement programme AMoRe has been essential in order to solve the structure. This dodecamer shows a unique conformation, quite different from all the previously studied oligonucleotide duplexes: the central octamer has an A conformation, but with a sharp 65 degrees kink in the centre; the terminal base-steps have a B-like conformation; the major groove is completely closed in the centre, a hollow molecule is thus found. The results obtained confirm the high degree of variability of DNA structure. A new type of kink and an intermediate A/B double-helical conformation have been found. Such intermediate conformation differs from those described in DNA polymerase complexes.

About this Structure

399D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structure of the d(CGCCCGCGGGCG) dodecamer: a kinked A-DNA molecule showing some B-DNA features., Malinina L, Fernandez LG, Huynh-Dinh T, Subirana JA, J Mol Biol. 1999 Jan 29;285(4):1679-90. PMID:9917405

Page seeded by OCA on Thu Mar 20 18:55:21 2008

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