3b4r

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[[Image:3b4r.jpg|left|200px]]<br /><applet load="3b4r" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:3b4r.jpg|left|200px]]
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caption="3b4r, resolution 3.30&Aring;" />
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'''Site-2 Protease from Methanocaldococcus jannaschii'''<br />
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{{Structure
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|PDB= 3b4r |SIZE=350|CAPTION= <scene name='initialview01'>3b4r</scene>, resolution 3.30&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Site-2 Protease from Methanocaldococcus jannaschii'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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3B4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4R OCA].
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3B4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B4R OCA].
==Reference==
==Reference==
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Structure of a site-2 protease family intramembrane metalloprotease., Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y, Science. 2007 Dec 7;318(5856):1608-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18063795 18063795]
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Structure of a site-2 protease family intramembrane metalloprotease., Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y, Science. 2007 Dec 7;318(5856):1608-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18063795 18063795]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc]]
[[Category: zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:03:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:56:03 2008''

Revision as of 16:56, 20 March 2008

Image:3b4r.jpg


PDB ID 3b4r

Drag the structure with the mouse to rotate
, resolution 3.30Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Site-2 Protease from Methanocaldococcus jannaschii


Overview

Regulated intramembrane proteolysis by members of the site-2 protease (S2P) family is an important signaling mechanism conserved from bacteria to humans. Here we report the crystal structure of the transmembrane core domain of an S2P metalloprotease from Methanocaldococcus jannaschii. The protease consists of six transmembrane segments, with the catalytic zinc atom coordinated by two histidine residues and one aspartate residue approximately 14 angstroms into the lipid membrane surface. The protease exhibits two distinct conformations in the crystals. In the closed conformation, the active site is surrounded by transmembrane helices and is impermeable to substrate peptide; water molecules gain access to zinc through a polar, central channel that opens to the cytosolic side. In the open conformation, transmembrane helices alpha1 and alpha6 separate from each other by 10 to 12 angstroms, exposing the active site to substrate entry. The structure reveals how zinc embedded in an integral membrane protein can catalyze peptide cleavage.

About this Structure

3B4R is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Structure of a site-2 protease family intramembrane metalloprotease., Feng L, Yan H, Wu Z, Yan N, Wang Z, Jeffrey PD, Shi Y, Science. 2007 Dec 7;318(5856):1608-12. PMID:18063795

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