3woz
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of CLASP2 TOG domain (TOG3)== |
| - | + | <StructureSection load='3woz' size='340' side='right' caption='[[3woz]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3woz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WOZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3woy|3woy]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3woz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3woz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3woz RCSB], [http://www.ebi.ac.uk/pdbsum/3woz PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/CLAP2_MOUSE CLAP2_MOUSE]] Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hayashi, I]] | [[Category: Hayashi, I]] | ||
| + | [[Category: Maki, T]] | ||
| + | [[Category: Heat repeat]] | ||
| + | [[Category: Microtubule]] | ||
| + | [[Category: Microtubule binding]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Tubulin]] | ||
| + | [[Category: Unknown]] | ||
Revision as of 15:56, 27 May 2015
Crystal structure of CLASP2 TOG domain (TOG3)
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