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4zet
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Blood dendritic cell antigen 2 (BDCA-2) complexed with GalGlcNAcMan== |
| - | + | <StructureSection load='4zet' size='340' side='right' caption='[[4zet]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zet]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZET FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zes|4zes]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zet OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zet RCSB], [http://www.ebi.ac.uk/pdbsum/4zet PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/CLC4C_HUMAN CLC4C_HUMAN]] Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.<ref>PMID:11748283</ref> <ref>PMID:11031109</ref> |
| - | [[ | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Drickamer, K]] | [[Category: Drickamer, K]] | ||
| - | [[Category: | + | [[Category: Dungarwalla, T]] |
| - | [[Category: Jegouzo, S | + | [[Category: Feinberg, H]] |
| + | [[Category: Jegouzo, S A.F]] | ||
| + | [[Category: Taylor, M E]] | ||
| + | [[Category: Weis, W I]] | ||
| + | [[Category: C-type lectin]] | ||
| + | [[Category: Carbohydrate-binding protein]] | ||
Revision as of 16:00, 27 May 2015
Blood dendritic cell antigen 2 (BDCA-2) complexed with GalGlcNAcMan
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