4zti

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m (Protected "4zti" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Ebola virus nucleoprotein bound to VP35 chaperoning peptide P212121==
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<StructureSection load='4zti' size='340' side='right' caption='[[4zti]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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The entry 4zti is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zti]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZTI FirstGlance]. <br>
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Authors: Kirchdoerfer, R.N., Abelson, D.M., Saphire, E.O.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zta|4zta]], [[4ztg|4ztg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zti OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zti RCSB], [http://www.ebi.ac.uk/pdbsum/4zti PDBsum]</span></td></tr>
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Description: Ebola virus nucleoprotein bound to VP35 chaperoning peptide P212121
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Saphire, E.O]]
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[[http://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
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[[Category: Kirchdoerfer, R.N]]
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== References ==
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[[Category: Abelson, D.M]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Abelson, D M]]
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[[Category: Kirchdoerfer, R N]]
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[[Category: Saphire, E O]]
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[[Category: Chaperone]]
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[[Category: Nucleoprotein]]
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[[Category: Rna-bindng]]
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[[Category: Viral protein]]

Revision as of 16:01, 27 May 2015

Ebola virus nucleoprotein bound to VP35 chaperoning peptide P212121

4zti, resolution 2.40Å

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