This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5aj8
From Proteopedia
(Difference between revisions)
| Line 6: | Line 6: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aj8 RCSB], [http://www.ebi.ac.uk/pdbsum/5aj8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aj8 RCSB], [http://www.ebi.ac.uk/pdbsum/5aj8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tubulin-binding cofactor C stimulates GTPase activity and contributes to the release of the heterodimeric alpha/#XPiS#betaetalpha;-tubulin from a super-complex of tubulin monomers and two ancillary cofactors. We have determined the 2.2 A resolution crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major based on single wavelength anomalous dispersion measurements targeting a selenomethionine derivative. Although previously predicted to consist of two domains the structure is best described as a single domain dominated by a right-handed beta-helix of five turns that form a triangular prism. One face of the prism is covered by the C-terminal residues leaving another face solvent exposed. Comparisons with an orthologous human GTPase activating protein match key residues involved in binding nucleotide and identify the face of the beta-helix fold likely involved in interacting with the beta-tubulin:GTP complex. | ||
| + | |||
| + | Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major.,Barrack KL, Fyfe PK, Finney AJ, Hunter WN Mol Biochem Parasitol. 2015 May 14. pii: S0166-6851(15)30002-5. doi:, 10.1016/j.molbiopara.2015.05.003. PMID:25982270<ref>PMID:25982270</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:47, 3 June 2015
Tubulin Binding Cofactor C from Leishmania major
| |||||||||||
