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3b7o
From Proteopedia
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| - | [[Image:3b7o.gif|left|200px]] | + | [[Image:3b7o.gif|left|200px]] |
| - | + | ||
| - | '''Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site''' | + | {{Structure |
| + | |PDB= 3b7o |SIZE=350|CAPTION= <scene name='initialview01'>3b7o</scene>, resolution 1.60Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MLT:MALATE ION'>MLT</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] | ||
| + | |GENE= PTPN11, PTP2C, SHPTP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site''' | ||
| + | |||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 3B7O is a [ | + | 3B7O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B7O OCA]. |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
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[[Category: sh2 domain]] | [[Category: sh2 domain]] | ||
[[Category: shp2]] | [[Category: shp2]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural genomics consortium]] | [[Category: structural genomics consortium]] | ||
[[Category: tyrosine phosphatase]] | [[Category: tyrosine phosphatase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:56:49 2008'' |
Revision as of 16:56, 20 March 2008
| |||||||
| , resolution 1.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | PTPN11, PTP2C, SHPTP2 (Homo sapiens) | ||||||
| Activity: | Protein-tyrosine-phosphatase, with EC number 3.1.3.48 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site
Disease
Known diseases associated with this structure: Leopard syndrome OMIM:[176876], Leukemia, juvenile myelomonocytic OMIM:[176876], Noonan syndrome 1 OMIM:[176876]
About this Structure
3B7O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Page seeded by OCA on Thu Mar 20 18:56:49 2008
Categories: Homo sapiens | Protein-tyrosine-phosphatase | Single protein | Arrowsmith, C H. | Barr, A. | Delft, F von. | Edwards, A M. | Elkins, J. | King, O. | Knapp, S. | Niesen, F. | Patel, A. | Pilka, E S. | SGC, Structural Genomics Consortium. | Salah, E. | Savitsky, P. | Ugochukwu, E. | Weigelt, J. | MLT | Alternative splicing | Cytoplasm | Deafness | Disease mutation | Hydrolase | Phosphorylation | Protein phosphatase | Ptpn11 | Sgc | Sh2 domain | Shp2 | Structural genomic | Structural genomics consortium | Tyrosine phosphatase
