5ajt
From Proteopedia
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| - | ''' | + | ==Crystal structure of ligand-free phosphoribohydrolase lonely guy from Claviceps purpurea== |
| + | <StructureSection load='5ajt' size='340' side='right' caption='[[5ajt]], [[Resolution|resolution]] 2.43Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ajt]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJT FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aju|5aju]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ajt RCSB], [http://www.ebi.ac.uk/pdbsum/5ajt PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The recently discovered cytokinin-specific phosphoribohydrolase 'Lonely Guy' (LOG) is a key enzyme of cytokinin biosynthesis, converting inactive cytokinin nucleotides into biologically active free-bases. We have determined the crystal structures of LOG from C. purpurea (cpLOG) and its complex with the enzymatic product phosphoribose. The structures reveal a dimeric arrangement of Rossmann folds, with the ligands bound to large pockets at the interface between cpLOG monomers. Structural comparisons highlight the homology of cpLOG to putative lysine decarboxylases. Extended sequence analysis enabled identification of a distinguishing LOG sequence signature. Taken together, our data suggest phosphoribohydrolase activity for several proteins of unknown function. This article is protected by copyright. All rights reserved. | ||
| - | The | + | The three-dimensional Structure of "Lonely Guy" from Claviceps purpurea provides insights into the phosphoribohydrolase function of Rossmann fold-containing lysine decarboxylase-like proteins.,Dzurova L, Forneris F, Savino S, Galuszka P, Vrabka J, Frebort I Proteins. 2015 May 25. doi: 10.1002/prot.24835. PMID:26010010<ref>PMID:26010010</ref> |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dzurova, L]] | ||
[[Category: Forneris, F]] | [[Category: Forneris, F]] | ||
[[Category: Savino, S]] | [[Category: Savino, S]] | ||
| - | [[Category: | + | [[Category: Cytokinin]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Lysine decarboxylase]] | ||
| + | [[Category: Rossmann fold]] | ||
Revision as of 12:31, 3 June 2015
Crystal structure of ligand-free phosphoribohydrolase lonely guy from Claviceps purpurea
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