4y61
From Proteopedia
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| - | ''' | + | ==Crystal structure of the complex between Slitrk2 LRR1 and PTP delta Ig1-Fn1== |
| + | <StructureSection load='4y61' size='340' side='right' caption='[[4y61]], [[Resolution|resolution]] 3.36Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4y61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y61 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y61 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y61 RCSB], [http://www.ebi.ac.uk/pdbsum/4y61 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SLIK2_MOUSE SLIK2_MOUSE]] Suppresses neurite outgrowth.<ref>PMID:14550773</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Selective binding between pre- and postsynaptic adhesion molecules can induce synaptic differentiation. Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2) and receptor protein tyrosine phosphatase (RPTP) delta. The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation. | ||
| - | + | Structure of Slitrk2-PTPdelta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.,Yamagata A, Sato Y, Goto-Ito S, Uemura T, Maeda A, Shiroshima T, Yoshida T, Fukai S Sci Rep. 2015 May 19;5:9686. doi: 10.1038/srep09686. PMID:25989451<ref>PMID:25989451</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Fukai, S]] | [[Category: Fukai, S]] | ||
| - | [[Category: | + | [[Category: Goto-Ito, S]] |
[[Category: Maeda, A]] | [[Category: Maeda, A]] | ||
| - | [[Category: | + | [[Category: Sato, Y]] |
[[Category: Shiroshima, T]] | [[Category: Shiroshima, T]] | ||
| - | [[Category: Goto-Ito, S]] | ||
[[Category: Uemura, T]] | [[Category: Uemura, T]] | ||
| + | [[Category: Yamgata, A]] | ||
| + | [[Category: Yoshida, T]] | ||
| + | [[Category: Hydrolase-signaling protein complex]] | ||
| + | [[Category: Trans-synaptic complex]] | ||
Revision as of 12:38, 3 June 2015
Crystal structure of the complex between Slitrk2 LRR1 and PTP delta Ig1-Fn1
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