3bct

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[[Image:3bct.gif|left|200px]]<br /><applet load="3bct" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:3bct.gif|left|200px]]
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caption="3bct, resolution 2.10&Aring;" />
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'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''<br />
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{{Structure
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|PDB= 3bct |SIZE=350|CAPTION= <scene name='initialview01'>3bct</scene>, resolution 2.10&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=URE:UREA'>URE</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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3BCT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=URE:'>URE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCT OCA].
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3BCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BCT OCA].
==Reference==
==Reference==
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Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9298899 9298899]
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Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9298899 9298899]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: cytoskeleton]]
[[Category: cytoskeleton]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:04:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:57:57 2008''

Revision as of 16:57, 20 March 2008

Image:3bct.gif


PDB ID 3bct

Drag the structure with the mouse to rotate
, resolution 2.10Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN


Overview

Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.

About this Structure

3BCT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899

Page seeded by OCA on Thu Mar 20 18:57:57 2008

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