4yvz
From Proteopedia
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| - | ''' | + | ==Structure of Thermotoga maritima DisA in complex with 3'-dATP/Mn2+== |
| - | + | <StructureSection load='4yvz' size='340' side='right' caption='[[4yvz]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yvz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3AT:3-DEOXYADENOSINE-5-TRIPHOSPHATE'>3AT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c1y|3c1y]], [[3c1z|3c1z]], [[3c21|3c21]], [[3c23|3c23]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yvz RCSB], [http://www.ebi.ac.uk/pdbsum/4yvz PDBsum]</span></td></tr> |
| - | [[Category: Hopfner, K | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Diadenylate cyclase]] | ||
| + | [[Category: Deimling, T]] | ||
| + | [[Category: Hopfner, K P]] | ||
[[Category: Mueller, M]] | [[Category: Mueller, M]] | ||
[[Category: Witte, G]] | [[Category: Witte, G]] | ||
| - | [[Category: | + | [[Category: C-di-amp synthesis]] |
| + | [[Category: Dac domain]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Pre-reaction state]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 12:47, 3 June 2015
Structure of Thermotoga maritima DisA in complex with 3'-dATP/Mn2+
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