Sandbox WI07

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Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).
Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).
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<scene name='70/703974/Tacrine between Trp84 ad Phe330/1'>Tacrine between Trp84 and F330</scene>
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<scene name='70/703974/Tacrine/1'>Tacrine between Trp84 and F330</scene>
<ref>PMID 8415649</ref>
<ref>PMID 8415649</ref>

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References

  1. Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
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