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3bk6
From Proteopedia
(New page: 200px<br /><applet load="3bk6" size="350" color="white" frame="true" align="right" spinBox="true" caption="3bk6, resolution 3.20Å" /> '''Crystal structure of...) |
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| - | [[Image:3bk6.jpg|left|200px]] | + | [[Image:3bk6.jpg|left|200px]] |
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| - | '''Crystal structure of a core domain of stomatin from Pyrococcus horikoshii''' | + | {{Structure |
| + | |PDB= 3bk6 |SIZE=350|CAPTION= <scene name='initialview01'>3bk6</scene>, resolution 3.20Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= PH1511 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of a core domain of stomatin from Pyrococcus horikoshii''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 3BK6 is a [ | + | 3BK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BK6 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a core domain of stomatin from Pyrococcus horikoshii Illustrates a novel trimeric and coiled-coil fold., Yokoyama H, Fujii S, Matsui I, J Mol Biol. 2008 Feb 22;376(3):868-78. Epub 2008 Jan 8. PMID:[http:// | + | Crystal structure of a core domain of stomatin from Pyrococcus horikoshii Illustrates a novel trimeric and coiled-coil fold., Yokoyama H, Fujii S, Matsui I, J Mol Biol. 2008 Feb 22;376(3):868-78. Epub 2008 Jan 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18182167 18182167] |
[[Category: Pyrococcus horikoshii]] | [[Category: Pyrococcus horikoshii]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: trimer]] | [[Category: trimer]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:59:44 2008'' |
Revision as of 16:59, 20 March 2008
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| , resolution 3.20Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | PH1511 (Pyrococcus horikoshii) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a core domain of stomatin from Pyrococcus horikoshii
Overview
Stomatin is a major integral membrane protein of human erythrocytes, the absence of which is associated with a form of hemolytic anemia known as hereditary stomatocytosis. However, the function of stomatin is not fully understood. An open reading frame, PH1511, from the hyperthermophilic archaeon Pyrococcus horikoshii encodes p-stomatin, a prokaryotic stomatin. Here, we report the first crystal structure of a stomatin ortholog, the core domain of the p-stomatin PH1511p (residues 56-234 of PH1511p, designated as PhSto(CD)). PhSto(CD) forms a novel homotrimeric structure. Three alpha/beta domains form a triangle of about 50 A on each side, and three alpha-helical segments of about 60 A in length extend from the apexes of the triangle. The alpha/beta domain of PhSto(CD) is partly similar in structure to the band-7 domain of mouse flotillin-2. While the alpha/beta domain is relatively rigid, the alpha-helical segment shows conformational flexibility, adapting to the neighboring environment. One alpha-helical segment forms an anti-parallel coiled coil with another alpha-helical segment from a symmetry-related molecule. The alpha-helical segment shows a heptad repeat pattern, and mainly hydrophobic residues form a coiled-coil interface. According to chemical cross-linking experiments, PhSto(CD) would be able to assemble into an oligomeric form. The coiled-coil fold observed in the crystal probably contributes to self-association.
About this Structure
3BK6 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.
Reference
Crystal structure of a core domain of stomatin from Pyrococcus horikoshii Illustrates a novel trimeric and coiled-coil fold., Yokoyama H, Fujii S, Matsui I, J Mol Biol. 2008 Feb 22;376(3):868-78. Epub 2008 Jan 8. PMID:18182167
Page seeded by OCA on Thu Mar 20 18:59:44 2008
Categories: Pyrococcus horikoshii | Single protein | Fujii, S. | Matsui, I. | Yokoyama, H. | Archaea | Coiled-coil | Flotillin | Membrane fusion | Membrane protein | Spfh | Stomatin | Trafficking | Transmembrane | Trimer
