2n02
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Solution structure of the A147T variant of the mitochondrial translocator protein (tspo) in complex with pk11195== |
| + | <StructureSection load='2n02' size='340' side='right' caption='[[2n02]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n02]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N02 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PKA:N-[(2R)-BUTAN-2-YL]-1-(2-CHLOROPHENYL)-N-METHYLISOQUINOLINE-3-CARBOXAMIDE'>PKA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2mgy|2mgy]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n02 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2n02 RCSB], [http://www.ebi.ac.uk/pdbsum/2n02 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Ligands of the transmembrane protein TSPO are used for imaging of brain inflammation, but a common polymorphism in TSPO complicates their application to humans. Here we determined the three-dimensional structure and side chain dynamics of the A147T polymorph of mammalian TSPO in complex with the first-generation ligand PK11195. We show that A147T TSPO is able to retain the same structural and dynamic profile of the wild-type protein and thus binds PK11195 with comparable affinity. Our study is important for the design of more potent diagnostic and therapeutic ligands of TSPO. | ||
| - | + | Structural integrity of the A147T polymorph of mammalian TSPO.,Jaremko M, Jaremko L, Giller K, Becker S, Zweckstetter M Chembiochem. 2015 May 12. doi: 10.1002/cbic.201500217. PMID:25974690<ref>PMID:25974690</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Becker, S]] | [[Category: Becker, S]] | ||
| + | [[Category: Giller, K]] | ||
| + | [[Category: Jaremko, L]] | ||
[[Category: Jaremko, M]] | [[Category: Jaremko, M]] | ||
| - | [[Category: Jaremko, L]] | ||
[[Category: Zweckstetter, M]] | [[Category: Zweckstetter, M]] | ||
| - | [[Category: | + | [[Category: A147t]] |
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Mitochondria]] | ||
| + | [[Category: Peripheral benzodiazepine receptor]] | ||
| + | [[Category: Pk11195]] | ||
| + | [[Category: Protein-ligand complex]] | ||
Revision as of 13:59, 10 June 2015
Solution structure of the A147T variant of the mitochondrial translocator protein (tspo) in complex with pk11195
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