4xco
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Signal-sequence induced conformational changes in the signal recognition particle== |
| + | <StructureSection load='4xco' size='340' side='right' caption='[[4xco]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4xco]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XCO FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ndb|3ndb]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xco RCSB], [http://www.ebi.ac.uk/pdbsum/4xco PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SRP54_METJA SRP54_METJA]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.[HAMAP-Rule:MF_00306] [[http://www.uniprot.org/uniprot/SRP19_METJA SRP19_METJA]] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-A structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180 degrees flip of the NG domain-structural changes that ensure a hierarchical succession of events during protein targeting. | ||
| - | + | Structural basis of signal-sequence recognition by the signal recognition particle.,Hainzl T, Huang S, Merilainen G, Brannstrom K, Sauer-Eriksson AE Nat Struct Mol Biol. 2011 Mar;18(3):389-91. Epub 2011 Feb 20. PMID:21336278<ref>PMID:21336278</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Hainzl, T]] | [[Category: Hainzl, T]] | ||
| + | [[Category: Sauer-Eriksson, A E]] | ||
| + | [[Category: Recombinant fusion protein]] | ||
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Rna structure]] | ||
| + | [[Category: Signal recognition particle]] | ||
| + | [[Category: Signal sequence]] | ||
Revision as of 14:02, 10 June 2015
Signal-sequence induced conformational changes in the signal recognition particle
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