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Sandbox-insulin-vered

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(New page: One of the CBI Molecules being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst in the [http://rob...)
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__NOTOC__
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==<center>'''הקסוסאמינידאז'''</center>==
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==Hexosaminidase==
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One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst in the [http://robertsgroup.ecs.umass.edu/ Roberts Research Group] and on display at the [http://www.molecularplayground.org Molecular Playground].
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<applet load='2gk1' size='400' frame='true' align='left' caption='Hexosaminidase'
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<StructureSection load='' size='500' side='right' scene='User:Whitney_Stoppel/sandbox1/Human_insulin2/1' caption='Human insulin chain A (grey) and chain B (green), [[3i40]]'>
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scene='Hexosaminidase_(Hebrew)/State0/3'/>
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[[Image:InsulinHexamer.jpg|200px|left]]&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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'''Insulin''' is a hormone that controls [[Carbohydrate Metabolism|carbohydrate metabolism]] and storage in the human body. The body is able to sense the concentration of glucose in the blood and respond by secreting insulin, which is produced by beta cells in the pancreas. Synthesis of human insulin in E. coli is important to producing insulin for the treatment of type 1 diabetes. Proinsulin (Pins) is processed by several proteases in the Golgi apparatus to form insulin which is shorter by 35 amino acids. DPI is a monomeric despentapeptide (B26-B30) Ins analogue. DTRI is a monomeric destripeptide (B28-B30) Ins analogue. DHPI is for desheptapeptide (B24-B30) Ins. LIns is a legume Ins.
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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insulin is made up of two pieces called the A- and B-chain, shown above in blue and green respectively. These two chains are joined by disulfide bonds, which are shown in yellow. This single piece made up of the A- and B-chains is the active form of the insulin hormone. This is the form that binds the insulin receptor on fat or muscle cells in the body, singling them to take up glucose, or sugar, from the blood and save it for later.
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<p dir='rtl'>
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הקסוס-אמינדאז הוא אנזים
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אשר נמצא בליזוזום של התא ותפקידו לפרק מולקולת גליקוליפיד בשם גנגליאוסיד. גליקוליפיד זה מצוי בממברנת התא והוא נוטל חלק בהעברת אותות
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</p>
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== <center>'''מבנה האנזים'''</center> ==
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<p dir='rtl'>
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האנזים בנוי <scene name='Hexosaminidase_(Hebrew)/State_0/2'>כהטרודימר</scene>, כלומר מורכב משתי שרשראות פולפפטידיות, שרשרת
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<scene name='Hexosaminidase_(Hebrew)/Alfachain/4'>אלפא</scene>
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ושרשרת
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<scene name='Hexosaminidase_(Hebrew)/Chain_b/3'>ביתא</scene>
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שלכל אחת מהן גן יחודי הקס אי והקס בי
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שרשרת אלפא בנויה מרצף של 529 <scene name='Hexosaminidase_(Hebrew)/Alfachain/5'>חומצות אמינו</scene> אשר מהוות את [http://www.pdb.org/pdb/explore/remediatedChain.do?structureId=2GK1&params.annotationsStr=dssp,scop&chainId=A המבנה הראשוני].(כל חומצה מסומנת בצבע שונה).
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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Insulin is able to pair-up with itself and form a dimer by forming hydrogen bonds between the ends of two B-chains. These <scene name='User:Whitney_Stoppel/sandbox1/Insulin_dimer/2'>hydrogen bonds</scene> are shown above in white. Then, 3 dimers can come together in the presence of zinc ions and form a hexamer. Insulin is stored in the <scene name='User:Whitney_Stoppel/sandbox1/Insulin_hexamer/4'>hexameric form</scene> in the body. This <scene name='User:Whitney_Stoppel/sandbox1/Insulin_ph7/2'>scene highlights</scene> the hydrophobic (gray) and polar (purple) parts of an insulin monomer at a pH of 7. It is believed that the hydrophobic sections on the B-chain cause insulin aggregation which initially caused problems in the manufacture and storage of insulin for [[Pharmaceutical_Drugs#Treatments|pharmaceutical use]].
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</StructureSection> For additional details see [[Insulin Structure & Function]].
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לשרשרת אלפא
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מבנה <scene name='Hexosaminidase_(Hebrew)/Second_structure/4'>שניוני</scene> הבנוי מאלפא הליקס (בצהוב) וביתא שיט (בירוק

Revision as of 07:44, 11 June 2015


הקסוסאמינידאז

Hexosaminidase

Hexosaminidase

Drag the structure with the mouse to rotate

הקסוס-אמינדאז הוא אנזים אשר נמצא בליזוזום של התא ותפקידו לפרק מולקולת גליקוליפיד בשם גנגליאוסיד. גליקוליפיד זה מצוי בממברנת התא והוא נוטל חלק בהעברת אותות

מבנה האנזים

האנזים בנוי , כלומר מורכב משתי שרשראות פולפפטידיות, שרשרת ושרשרת שלכל אחת מהן גן יחודי הקס אי והקס בי שרשרת אלפא בנויה מרצף של 529 אשר מהוות את המבנה הראשוני.(כל חומצה מסומנת בצבע שונה). לשרשרת אלפא מבנה הבנוי מאלפא הליקס (בצהוב) וביתא שיט (בירוק

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