2mx1
From Proteopedia
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| - | ''' | + | ==Structure of the E. coli Threonylcarbamoyl-AMP Synthase TSAC== |
| - | + | <StructureSection load='2mx1' size='340' side='right' caption='[[2mx1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2mx1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MX1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-threonylcarbamoyladenylate_synthase L-threonylcarbamoyladenylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.87 2.7.7.87] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mx1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mx1 RCSB], [http://www.ebi.ac.uk/pdbsum/2mx1 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/TSAC_ECOLI TSAC_ECOLI]] Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles.[HAMAP-Rule:MF_01852]<ref>PMID:15716138</ref> <ref>PMID:19287007</ref> <ref>PMID:21285948</ref> <ref>PMID:22378793</ref> <ref>PMID:23072323</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: L-threonylcarbamoyladenylate synthase]] | ||
| + | [[Category: Agris, P F]] | ||
| + | [[Category: Bilbille, Y]] | ||
| + | [[Category: Bobay, B G]] | ||
[[Category: Deutsch, C]] | [[Category: Deutsch, C]] | ||
| - | [[Category: | + | [[Category: Harris, K A]] |
[[Category: Iwata-Reuyl, D]] | [[Category: Iwata-Reuyl, D]] | ||
| - | [[Category: | + | [[Category: Sarachan, K L]] |
| - | [[Category: | + | [[Category: Sims, A F]] |
| + | [[Category: Transferase]] | ||
Revision as of 15:19, 17 June 2015
Structure of the E. coli Threonylcarbamoyl-AMP Synthase TSAC
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