4zqm

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m (Protected "4zqm" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with XMP and NAD==
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<StructureSection load='4zqm' size='340' side='right' caption='[[4zqm]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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The entry 4zqm is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zqm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQM FirstGlance]. <br>
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Authors: Kim, Y., Maltseva, N., Makowska-Grzyska, M., Gu, M., Kavitha, M., Hedstrom, L., Andesrson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=XMP:XANTHOSINE-5-MONOPHOSPHATE'>XMP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zqn|4zqn]], [[4zqo|4zqo]], [[4zqp|4zqp]], [[4zqr|4zqr]]</td></tr>
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Description: Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with XMP and NAD
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zqm RCSB], [http://www.ebi.ac.uk/pdbsum/4zqm PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Andesrson, W.F]]
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== Function ==
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[[http://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
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__TOC__
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</StructureSection>
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[[Category: Andesrson, W F]]
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[[Category: Structural genomic]]
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[[Category: Gu, M]]
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[[Category: Hedstrom, L]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak, A]]
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[[Category: Makowska-Grzyska, M]]
 
[[Category: Kavitha, M]]
[[Category: Kavitha, M]]
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[[Category: Maltseva, N]]
 
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[[Category: Hedstrom, L]]
 
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[[Category: Gu, M]]
 
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[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
 
[[Category: Kim, Y]]
[[Category: Kim, Y]]
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[[Category: Makowska-Grzyska, M]]
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[[Category: Maltseva, N]]
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[[Category: Csgid]]
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[[Category: Delta-cb]]
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[[Category: Impdh]]
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[[Category: Mycobacterium tuberculosis]]

Revision as of 15:33, 17 June 2015

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with XMP and NAD

4zqm, resolution 1.60Å

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