This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4zqn
From Proteopedia
(Difference between revisions)
m (Protected "4zqn" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | ''' | + | ==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor P41== |
| - | + | <StructureSection load='4zqn' size='340' side='right' caption='[[4zqn]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zqn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4QO:2-CHLORO-N,N-DIMETHYL-5-[({2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}CARBAMOYL)AMINO]BENZAMIDE'>4QO</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zqm|4zqm]], [[4zqo|4zqo]], [[4zqp|4zqp]], [[4zqr|4zqr]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zqn RCSB], [http://www.ebi.ac.uk/pdbsum/4zqn PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Andesrson, W F]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Gu, M]] | ||
| + | [[Category: Hedstrom, L]] | ||
[[Category: Joachimiak, A]] | [[Category: Joachimiak, A]] | ||
| - | [[Category: Makowska-Grzyska, M]] | ||
[[Category: Kavitha, M]] | [[Category: Kavitha, M]] | ||
| - | [[Category: Hedstrom, L]] | ||
| - | [[Category: Gu, M]] | ||
| - | [[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]] | ||
[[Category: Kim, Y]] | [[Category: Kim, Y]] | ||
| + | [[Category: Makowska-Grzyska, M]] | ||
| + | [[Category: Csgid]] | ||
| + | [[Category: Delta cb]] | ||
| + | [[Category: Impdh]] | ||
| + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
Revision as of 15:33, 17 June 2015
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor P41
| |||||||||||
