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5a3w
From Proteopedia
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| - | ''' | + | ==Crystal structure of human PLU-1 (JARID1B) in complex with Pyridine-2, 6-dicarboxylic Acid (PDCA)== |
| - | + | <StructureSection load='5a3w' size='340' side='right' caption='[[5a3w]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5a3w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A3W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PD2:PYRIDINE-2,4-DICARBOXYLIC+ACID'>PD2</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a3n|5a3n]], [[5a3t|5a3t]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a3w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5a3w RCSB], [http://www.ebi.ac.uk/pdbsum/5a3w PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
| - | [[Category: | + | [[Category: Burgess-Brown, N A]] |
| - | [[Category: | + | [[Category: Delft, F Von]] |
| + | [[Category: Edwards, A M]] | ||
[[Category: Gileadi, C]] | [[Category: Gileadi, C]] | ||
| - | [[Category: Oppermann, U]] | ||
| - | [[Category: Kopec, J]] | ||
| - | [[Category: Von Delft, F]] | ||
| - | [[Category: Edwards, A.M]] | ||
[[Category: Johansson, C]] | [[Category: Johansson, C]] | ||
| - | [[Category: | + | [[Category: Kopec, J]] |
| + | [[Category: Kupinska, K]] | ||
| + | [[Category: Oppermann, U]] | ||
[[Category: Srikannathasan, V]] | [[Category: Srikannathasan, V]] | ||
| + | [[Category: Strain-Damerell, C]] | ||
| + | [[Category: Lysine-specific demethylase 5b]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 15:34, 17 June 2015
Crystal structure of human PLU-1 (JARID1B) in complex with Pyridine-2, 6-dicarboxylic Acid (PDCA)
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