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T-cell receptor
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_2xna| PDB=2xna | SIZE=400| SCENE= |right|CAPTION= T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].}} | {{STRUCTURE_2xna| PDB=2xna | SIZE=400| SCENE= |right|CAPTION= T-cell receptor α chain (grey), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) [[2xna]].}} | ||
| - | '''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits TCR heterodimer. For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]]. | + | '''T-cell receptors''' (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits TCR heterodimer. TCR NKT reside in Ntural Killer T-cells. For more details see [[SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex]]. |
== 3D structures of T-cell receptor== | == 3D structures of T-cell receptor== | ||
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*TCR α+β chains | *TCR α+β chains | ||
| - | **[[1tcr]], [[2z35]] – mTCR α+β chains<br /> | + | **[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br /> |
**[[1tcr]], [[2q86]] – mTCR α+β chains (mutant)<br /> | **[[1tcr]], [[2q86]] – mTCR α+β chains (mutant)<br /> | ||
**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br /> | **[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br /> | ||
**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]] – hTCR α+β chains<br /> | **[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]] – hTCR α+β chains<br /> | ||
**[[4ei6]] – h/mTCR α+β chains <br /> | **[[4ei6]] – h/mTCR α+β chains <br /> | ||
| - | **[[2ial]], [[4gg8]] – hTCR α+β chains (mutant)<br /> | + | **[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br /> |
**[[3of6]] – hTCR pre-α+β (mutant) chains<br /> | **[[3of6]] – hTCR pre-α+β (mutant) chains<br /> | ||
| + | |||
| + | *TCR α+β+γ chains | ||
| + | |||
| + | **[[4mnh]] – hTCR α+β+γ chains<br /> | ||
*TCR γ+δ chains | *TCR γ+δ chains | ||
**[[1hxm]], [[3omz]] – hTCR γ+δ chains<br /> | **[[1hxm]], [[3omz]] – hTCR γ+δ chains<br /> | ||
| + | **[[4ndm]] – hTCR γ+δ chains (mutant)<br /> | ||
*TCR complex with antigen | *TCR complex with antigen | ||
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*TCR complex with MHC and antigen | *TCR complex with MHC and antigen | ||
| - | **[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> | + | **[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> |
| - | **[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]] – hTCR α+β chains + MHC + polypeptide <br /> | + | **[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br /> |
| + | **[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br /> | ||
| + | **[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
**[[3o6f]] – hTCR α+β chains + MHC <br /> | **[[3o6f]] – hTCR α+β chains + MHC <br /> | ||
**[[3pl6]] – hTCR α chain + MHC + polypeptide <br /> | **[[3pl6]] – hTCR α chain + MHC + polypeptide <br /> | ||
| - | **[[2xn9 | + | **[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br /> |
| - | + | ||
| - | + | ||
**[[3t0e]] – hTCR α+β chains + MHC + CD4 <br /> | **[[3t0e]] – hTCR α+β chains + MHC + CD4 <br /> | ||
| - | **[[3o8x]], [[3o9w]], [[4ei5]] – h/mTCR α+β chains + β-2 microglobulin + CD1D <br /> | ||
| - | **[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br /> | ||
**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | **[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | **[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
| + | **[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br /> | ||
**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> | **[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br /> | ||
| + | **[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br /> | ||
**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br /> | **[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br /> | ||
**[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br /> | **[[2icw]] – mTCR α+β chains + MHC + mycoplasma arthritidis mitogen + polypeptide <br /> | ||
| - | **[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]] – mTCR α+β chains + MHC + polypeptide <br /> | + | **[[1d9k]], [[2e7l]], [[2oi9]], [[2z31]], [[3e2h]], [[3e3q]], [[3qib]], [[3mbe]] – mTCR α+β chains + MHC + polypeptide <br /> |
**[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br /> | **[[1u3h]] – mTCR α+β chains (mutant) + MHC + polypeptide <br /> | ||
**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br /> | **[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br /> | ||
| + | |||
| + | *TCR complex with CD1D | ||
| + | |||
| + | **[[3huj]], [[3vwj]], [[3vwk]], [[4en3]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br /> | ||
| + | **[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br /> | ||
| + | **[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br /> | ||
| + | **[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br /> | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 06:58, 18 June 2015
T-cell receptors (TCR) reside on the surface of T lymphocytes. TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. The binding of TCR to the antigen-MHC activates the T lymphocytes. TCR is a heterodimer of α+β subunits and ca. 5% the T cells have a γ+δ subumits TCR heterodimer. TCR NKT reside in Ntural Killer T-cells. For more details see SP3.4-TCR-HLA-DQ8-∝-1-gliadin_complex.
3D structures of T-cell receptor
Updated on 18-June-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
