This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Thioredoxin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 33: Line 33:
**[[3e3e]], [[2hsh]], [[1aiu]], [[1erv]], [[1erw]], [[3m9j]], [[3m9k]], [[4oo4]] – hTrx (mutant) – human<br />
**[[3e3e]], [[2hsh]], [[1aiu]], [[1erv]], [[1erw]], [[3m9j]], [[3m9k]], [[4oo4]] – hTrx (mutant) – human<br />
-
**[[3kd0]] - hTrx (mutant)+CdCl2<br />
 
-
**[[1cqg]], [[1cqh]] - hTrx (mutant)+Ref-1 peptide – NMR<br />
 
-
**[[1mdi]], [[1mdj]], [[1mdk]] - hTrx + Target peptide of NFKB – NMR<br />
 
**[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br />
**[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br />
**[[4oo5]] - hTrx S-nitroso (mutant)<br />
**[[4oo5]] - hTrx S-nitroso (mutant)<br />
Line 42: Line 39:
**[[3hyp]] - BfrxI fragment (mutant)<br />
**[[3hyp]] - BfrxI fragment (mutant)<br />
**[[3hz4]] – Trx – ''Methanosarcina mazei''<br />
**[[3hz4]] – Trx – ''Methanosarcina mazei''<br />
-
**[[2k9f]] - Trx fragment+DsbD N-terminal – ''Neisseria meningitides'' – NMR<br />
 
**[[3die]] – SaTrx (mutant) – ''Staphylococcus aureus''<br />
**[[3die]] – SaTrx (mutant) – ''Staphylococcus aureus''<br />
**[[2voc]] - BsTrx (mutant) – ''Bacillus subtilis''<br />
**[[2voc]] - BsTrx (mutant) – ''Bacillus subtilis''<br />
**[[2gzy]], [[2gzz]] – BsTrx – NMR<br />
**[[2gzy]], [[2gzz]] – BsTrx – NMR<br />
-
**[[2ipa]] – BsTrx (mutant)+ArcS (mutant) - NMR<br />
 
**[[2h6x]], [[2trx]], [[1srx]] – EcTrx<br />
**[[2h6x]], [[2trx]], [[1srx]] – EcTrx<br />
**[[1xoa]], [[1xob]] – EcTrx - NMR<br />
**[[1xoa]], [[1xob]] – EcTrx - NMR<br />
**[[1m7t]] – hTrx/EcTrx chimera - NMR<br />
**[[1m7t]] – hTrx/EcTrx chimera - NMR<br />
-
**[[3dxb]] – hTrx+Puf60 C-terminal<br />
 
**[[3emx]] – Trx – ''Aeropyrum pernix''<br />
**[[3emx]] – Trx – ''Aeropyrum pernix''<br />
**[[2vim]] – Trx – ''Fasciola hepatica''<br />
**[[2vim]] – Trx – ''Fasciola hepatica''<br />
-
**[[2yzu]], [[2cvk]], [[1v98]] – TtTrx – ''Thermus thermophilus''<br />
+
**[[2yzu]], [[2cvk]], [[1v98]], [[4tn8]] – TtTrx – ''Thermus thermophilus''<br />
**[[2lst]] – TtTrx - NMR<br />
**[[2lst]] – TtTrx - NMR<br />
**[[2e0q]] – Trx (mutant) – ''Sulfolobus tokodaii''<br />
**[[2e0q]] – Trx (mutant) – ''Sulfolobus tokodaii''<br />
Line 65: Line 59:
**[[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br />
**[[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br />
**[[1syr]] – PfTrx – ''Plasmodium falciparum''<br />
**[[1syr]] – PfTrx – ''Plasmodium falciparum''<br />
 +
**[[2mmn]], [[2mmo]] - PfTrx - NMR<br />
**[[1r26]] – Trx – ''Trypanosoma brucei brucei''<br />
**[[1r26]] – Trx – ''Trypanosoma brucei brucei''<br />
**[[1gl8]] – Trx – spinach - NMR<br />
**[[1gl8]] – Trx – spinach - NMR<br />
Line 74: Line 69:
**[[2xbq]], [[2xc2]] – SmTrx (mutant)<br />
**[[2xbq]], [[2xc2]] – SmTrx (mutant)<br />
**[[4i8b]] - Trx – ''Schistosoma japonicum''<br />
**[[4i8b]] - Trx – ''Schistosoma japonicum''<br />
-
**[[3zzx]], [[4aj8]], [[4aj7]], [[4aj6]] – Trx – ''Litopenaeus vannamei''<br />
+
**[[3zzx]], [[4aj8]], [[4aj7]], [[4aj6]], [[4v2l]], [[4v2m]], [[4v2n]] – Trx – ''Litopenaeus vannamei''<br />
**[[4fyu]] – Trx – ''Wuchereria bancrofti''<br />
**[[4fyu]] – Trx – ''Wuchereria bancrofti''<br />
**[[4knd]] – Trx – ''Anaeromyxobacter dehalogenans''<br />
**[[4knd]] – Trx – ''Anaeromyxobacter dehalogenans''<br />
Line 84: Line 79:
**[[2yj7]], [[2yn1]], [[2yoi]], [[2ypm]], [[3ziv]], [[4ba7]] – ancestral Trx – synthetic<br />
**[[2yj7]], [[2yn1]], [[2yoi]], [[2ypm]], [[3ziv]], [[4ba7]] – ancestral Trx – synthetic<br />
**[[4pob]] – Trx – ''Mycobacterium abscessus''<br />
**[[4pob]] – Trx – ''Mycobacterium abscessus''<br />
 +
**[[2ynx]], [[4ulx]] – Trx – Last Archaea Common Ancestor<br />
 +
**[[4cw9]] - Trx (mutant) – ''Entamoeba histolytica''<br />
 +
**[[4wxt]] - Trx – ''Mycobacterium avium''<br />
 +
 +
*Thioredoxin complexes
 +
 +
**[[3kd0]] - hTrx (mutant)+CdCl2<br />
 +
**[[4pok]], [[4pol]], [[4pom]] - hTrx (mutant)+ thioethanesulfonate<br />
 +
**[[4puf]] - hTrx (mutant)+ E3 ubiquitin-protein ligase<br />
 +
**[[1cqg]], [[1cqh]] - hTrx (mutant)+Ref-1 peptide – NMR<br />
 +
**[[1mdi]], [[1mdj]], [[1mdk]] - hTrx + Target peptide of NFKB – NMR<br />
 +
**[[3dxb]] – hTrx+Puf60 C-terminal<br />
 +
**[[2k9f]] - Trx fragment+DsbD N-terminal – ''Neisseria meningitides'' – NMR<br />
 +
**[[2ipa]] – BsTrx (mutant)+ArcS (mutant) - NMR<br />
*Thioredoxin 1
*Thioredoxin 1
Line 119: Line 128:
**[[2ppt]] – Trx-2 – ''Rhodobacter capsulatus''<br />
**[[2ppt]] – Trx-2 – ''Rhodobacter capsulatus''<br />
**[[1thx]] – Trx-2 – Anabaena<br />
**[[1thx]] – Trx-2 – Anabaena<br />
-
**[[3ul3]] – PfTrx-2
+
**[[3ul3]], [[4o32]] – PfTrx-2
*Thioredoxin 3
*Thioredoxin 3
-
**[[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3
+
**[[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3<br />
 +
**[[4xhm]] – Trx-3 – ''Archaeoglobus fulgidus''<br />
*Thioredoxin C
*Thioredoxin C

Revision as of 10:21, 18 June 2015

Image:1ert.png
Crystal Structure of Thioredoxin 1ert

Template:STRUCTURE 3kd0










Thioredoxin (Trx) is an enzyme which facilitates the reduction of proteins by cysteine thiol-disulfide exchange. They contain a CXXC motif.

  • Trx-1 is a mammalian cellular protein.
  • Trx-2 is mitochondria-specific.

In higher plants, Trx are divided to 6 groups based on their sequence. Trx M, X and Y are found in prokaryotes while F, H and O are found in eukaryotes.

3D Structures of Thioredoxin

Updated on 18-June-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Thioredoxin"
Personal tools