Thymidylate kinase
From Proteopedia
(Difference between revisions)
| Line 56: | Line 56: | ||
**[[4gfd]], [[4hlc]], [[4hld]], [[4hej]], [[4hdc]] – SaTMK + antibacterial drug <br /> | **[[4gfd]], [[4hlc]], [[4hld]], [[4hej]], [[4hdc]] – SaTMK + antibacterial drug <br /> | ||
| - | **[[4gsy]] – SaTMK + inhibitor<br /> | + | **[[4gsy]], [[4qg7]], [[4xwa]] – SaTMK + inhibitor<br /> |
| + | **[[4qg7]], [[4qgf]], [[4qgg]], [[4qgh]] – SaTMK (mutant) + inhibitor<br /> | ||
**[[4mqb]] – SaTMK + MES<br /> | **[[4mqb]] – SaTMK + MES<br /> | ||
| + | **[[4unp]] – MtTMK + inhibitor<br /> | ||
*Thymidylate kinase complex with bisubstrate inhibitor | *Thymidylate kinase complex with bisubstrate inhibitor | ||
Revision as of 05:59, 21 June 2015
Thymidylate kinase (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. The TMK inhibitor azido-dTMP (AZTP) is an HIV AZT prodrug metabolite.
3D Structures of thymidylate kinase
Updated on 21-June-2015
