Thymidylate synthase
From Proteopedia
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**[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]]- hTS – human<br /> | **[[1hw3]], [[1hw4]], [[1hzw]], [[1ypv]], [[2onb]], [[4gyh]], [[4h1i]]- hTS – human<br /> | ||
**[[3n5g]], [[4kpw]] – hTS His-tag<br /> | **[[3n5g]], [[4kpw]] – hTS His-tag<br /> | ||
| - | **[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]] – hTS (mutant)<br /> | + | **[[2rd8]], [[2rda]], [[3egy]], [[3ehi]], [[3eaw]], [[3ebu]], [[3ed7]], [[3edw]], [[3ef9]], [[3ejl]], [[3gg5]], [[3gh0]], [[3gh2]], [[4jef]], [[4o1u]], [[4o1x]] – hTS (mutant)<br /> |
**[[3ix6]] – BmTS – ''Brucella melitensis''<br /> | **[[3ix6]] – BmTS – ''Brucella melitensis''<br /> | ||
**[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br /> | **[[3kgb]] – TS – ''Encephalitozoon cuniculi''<br /> | ||
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**[[4e5o]] - mTS + UMP<BR /> | **[[4e5o]] - mTS + UMP<BR /> | ||
**[[4ein]] – mTS + substrate analog<br /> | **[[4ein]] – mTS + substrate analog<br /> | ||
| - | **[[3uwl]] – | + | **[[3uwl]] – EfTS + 5-formyl tetrahydrofolate – ''Enterococcus faecalis''<br > |
| + | **[[4psg]] – TS + inhibitor – ''Caenorhabditis elegans''<br > | ||
**[[4g9u]] – TS + UMP – ''Trichinella spiralis''<br /> | **[[4g9u]] – TS + UMP – ''Trichinella spiralis''<br /> | ||
**[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br /> | **[[4foa]] - MtTS + fluoro-UMP – ''Mycobacterium tuberculosis''<br /> | ||
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**[[4eb4]] - mTS + drug + UMP<BR /> | **[[4eb4]] - mTS + drug + UMP<BR /> | ||
**[[4iqq]] – nTS + UMP + raltitrexed<br /> | **[[4iqq]] – nTS + UMP + raltitrexed<br /> | ||
| + | **[[4o7u]] - EfTS + phthalimidic derivative + folate derivative<br /> | ||
*'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]] | *'''Bifunctional dihydrofolate reductase-thymidylate synthase''' see [[Dihydrofolate reductase]] | ||
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**[[4gtc]], [[4gtl]], [[4kar]] – TmTS (mutant) + FAD <br /> | **[[4gtc]], [[4gtl]], [[4kar]] – TmTS (mutant) + FAD <br /> | ||
**[[1o26]] – TmTS + FAD + UMP<br /> | **[[1o26]] – TmTS + FAD + UMP<br /> | ||
| + | **[[4gtd]], [[4kas]], [[4kat]] – TmTS (mutant) + FAD + UMP<br /> | ||
**[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br /> | **[[1o27]], [[1o28]], [[1o29]] – TmTS + FAD + halo-UMP<br /> | ||
**[[1o2b]] – TmTS + FAD + phosphate<br /> | **[[1o2b]] – TmTS + FAD + phosphate<br /> | ||
Revision as of 06:17, 21 June 2015
Template:STRUCTURE 4tmk Thymidylate synthase (TS) catalyzes the methylation of dUMP to dTMP using 5,10-methylenetetrahydrofolate as a cofactor. TS is essential for DNA replication and repair. TS inhibition at its folate-binding site is used in anticancer therapeutic drugs. In protozoa, dihydrofolate reductase (DHFR) and TS are expressed as a bifunctional monomeric enzyme (DHFR-TS) with the DHFR entity at the N terminal. DHFR and TS catalyze consecutive reactions in the dTMP biosynthesis. DHFR-TS inhibitors are potential drug targets against parasite-transferred diseases. There are two different types of TS – ThyA and ThyX. The types differ in their activity and structure. The TS ThyX are flavin-dependent enzymes.
3D structures of thymidylate synthase
Updated on 21-June-2015
Proteopedia Page Contributors and Editors (what is this?)
Michael O'Shaughnessy, Karsten Theis, Michal Harel, Alexander Berchansky, Shaylie Albright, Anna Postnikova, Kia Yang, Joel L. Sussman
