Tryptophan synthase
From Proteopedia
(Difference between revisions)
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**[[1v8z]] - PfTrpS β subunit <br /> | **[[1v8z]] - PfTrpS β subunit <br /> | ||
**[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br /> | **[[4neg]] - TrpS β subunit – ''Bacillus anthracis''<br /> | ||
| + | **[[4qys]] - TrpS β subunit – ''Sulfolobus solfataricus''<br /> | ||
*Tryptophan synthase β binary complex | *Tryptophan synthase β binary complex | ||
Revision as of 10:28, 22 June 2015
Tryptophan synthase (TrpS) is an α2β2 tetramer participating in the biosynthesis of tryptophan. TrpS α subunit catalyzes the formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol phosphate (IGP). The β subunit catalyzes in a pyridoxal-phosphate (PLP) dependent reaction the formation of tryptophan (Trp) from indole and serine. The diffusion of indole from the α to the β subunit is facilitated via a hydrophobic channel connecting the subunits. TrpS is not found in animals hence it is tested as a possible drug target for tubertculosis, ocular and genital infections, cryptosporidiosis and as herbicide.
3D structures of tryptophan synthase
Updated on 22-June-2015
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Amer Ali
