Tumor necrosis factor
From Proteopedia
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<StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> | <StructureSection load='2az5' size='350' side='right' caption='Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry [[2az5]])' scene=''> | ||
| - | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease | + | '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNFα-converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]). |
</StructureSection> | </StructureSection> | ||
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**[[3alq]] – hTNF (mutant) + TNF receptor <BR /> | **[[3alq]] – hTNF (mutant) + TNF receptor <BR /> | ||
**[[4g3y]], [[3wd5]] – hTNF + antibody <BR /> | **[[4g3y]], [[3wd5]] – hTNF + antibody <BR /> | ||
| + | **[[4twt]] – hTNF + peptide <BR /> | ||
*TNF beta | *TNF beta | ||
Revision as of 07:51, 23 June 2015
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3D Structures of tumor necrosis factor
Updated on 23-June-2015
